Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6922213 | 0.82 | ALDH1A1 (0.55) | ALDH1A1LMNAHPGDGAASMN1; SMN2 | |
| SCHEMBL2335513 | 0.81 | ALDH1A1 (0.50) | ALDH1A1LMNAHPGDGAASMN1; SMN2 | |
| SCHEMBL2335508 | 0.78 | ALDH1A1 (0.56) | ALDH1A1LMNAHPGDGAASMN1; SMN2 | |
| SCHEMBL13864485 | 0.78 | ALDH1A1 (0.55) | ALDH1A1LMNAHPGDSMN1; SMN2KMT2A | |
| SCHEMBL6926699 | 0.78 | LMNA (0.48) | ALDH1A1LMNAHPGDSMN1; SMN2KMT2A | |
| SCHEMBL8973826 | 0.76 | TDP1 (0.57) | ALDH1A1LMNAHPGDGAASMN1; SMN2 | |
| SCHEMBL4364949 | 0.76 | ALDH1A1 (0.53) | ALDH1A1LMNAHPGDGAASMN1; SMN2 | |
| SCHEMBL4361623 | 0.75 | TDP1 (0.53) | ALDH1A1LMNAHPGDGAASMN1; SMN2 | |
| SCHEMBL922726 | 0.74 | TDP1 (0.58) | ALDH1A1LMNAHPGDSMN1; SMN2KMT2A | |
| SCHEMBL30780913 | 0.74 | TDP1 (0.58) | ALDH1A1LMNAHPGDGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001766-B1 | COMPOUNDS FOR THE TREATMENT OF CCR5-MEDIATED DISEASES | SMITHKLINE BEECHAM CORP (US) | 2003-04-09 | — | — | EP | disclosed |
| US-6515027-B1 | Ligands, agonists or antagonists, of the CC chemokine receptor CC-CKR5 | SMITHKLINE BEECHAM CORP. | 2003-02-04 | — | — | US | disclosed |
| EP-1001766-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2001-04-04 | — | — | EP | disclosed |
| EP-1001766-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999001127-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-01-14 | — | — | WO | disclosed |