Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCK | P08631 | 5/20 | 0.36 |
| ▸ | FLT3 | P36888 | 5/20 | 0.36 |
| ▸ | SRC | P12931 | 8/20 | 0.34 |
| ▸ | ABL1 | P00519 | 8/20 | 0.33 |
| ▸ | EGFR | P00533 | 7/20 | 0.33 |
| ▸ | ABL2 | P42684 | 6/20 | 0.33 |
| ▸ | LCK | P06239 | 5/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 4/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.32 |
| ▸ | PAK4 | O96013 | 2/20 | 0.32 |
| ▸ | FYN | P06241 | 2/20 | 0.32 |
| ▸ | CSF1R | P07333 | 2/20 | 0.32 |
| ▸ | RET | P07949 | 2/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.32 |
| ▸ | FLT1 | P17948 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.32 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.32 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10198690 | 0.81 | SRC (0.47) | HCKFLT3SRCABL1EGFR | |
| SCHEMBL10198694 | 0.75 | SRC (0.42) | FLT3SRCABL1LCKMAP4K4 | |
| SCHEMBL16386305 | 0.74 | YTHDC1 (0.41) | SRCEGFR | |
| SCHEMBL6926735 | 0.71 | SRC (0.50) | HCKFLT3SRCABL1EGFR | |
| SCHEMBL6926802 | 0.71 | SRC (0.51) | FLT3SRCABL1EGFRABL2 | |
| SCHEMBL10198695 | 0.71 | SRC (0.49) | HCKFLT3SRCABL1EGFR | |
| SCHEMBL6925160 | 0.69 | RET (0.52) | HCKFLT3SRCABL1EGFR | |
| SCHEMBL6927761 | 0.68 | SRC (0.39) | SRCLCKRETKDRTEK | |
| SCHEMBL14643787 | 0.67 | ADK (0.52) | FLT3SRCABL1EGFRABL2 | |
| SCHEMBL6927089 | 0.67 | SRC (0.55) | HCKFLT3SRCABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |