Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 known ✓ | P25103 | 4/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6927034 | 0.87 | TACR1 (0.34) | TACR1ADORA2AADORA1CNR1CNR2 | |
| Hydrochloric Acid SCHEMBL8366175 | 0.79 | TACR1 (0.36) | TACR1MEN1CYP1A2POLBCYP2C9 | |
| Hydrochloric Acid SCHEMBL8361917 | 0.79 | TACR1 (0.36) | TACR1MEN1CYP1A2POLBCYP2C9 | |
| Hydrochloric Acid SCHEMBL8361840 | 0.77 | TACR1 (0.33) | TACR1MEN1CYP1A2POLBCYP2C9 | |
| Hydrochloric Acid SCHEMBL8084823 | 0.75 | CNR1 (0.35) | TACR1MEN1CYP1A2POLBCYP2C9 | |
| Hydrochloric Acid SCHEMBL7639533 | 0.72 | CNR1 (0.35) | TACR1ADORA2AADORA1CNR1CNR2 | |
| Hydrochloric Acid SCHEMBL6930149 | 0.71 | TACR1 (0.37) | TACR1MEN1CYP1A2POLBCYP2C9 | |
| Hydrochloric Acid SCHEMBL6924045 | 0.71 | TACR1 (0.37) | TACR1MEN1CYP1A2POLBCYP2C9 | |
| Hydrochloric Acid SCHEMBL7652901 | 0.71 | CNR1 (0.35) | TACR1ADORA2AADORA1CNR1CNR2 | |
| Hydrochloric Acid SCHEMBL7634793 | 0.70 | TACR1 (0.32) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518378-B2 | Using an unbridged cyclopentadienyl metallocene catalyst capable of interconverting between states with different copolymerization characteristics | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2003-02-11 | — | — | US | disclosed |
| US-20010049425-A1 | High-melting polyolefin copolymer elastomers, catalysts and methods of synthesis | BP CORPORATION NORTH AMERICA INC. | 2001-12-06 | — | — | US | disclosed |
| US-20010034426-A1 | High-melting polyolefin copolymer elastomers, catalysts and methods of synthesis | BP CORPORATION NORTH AMERICA INC. | 2001-10-25 | — | — | US | disclosed |