Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 known ✓ | P25103 | 13/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 3/20 | 0.32 |
| ▸ | RXRB | P28702 | 3/20 | 0.32 |
| ▸ | RXRG | P48443 | 2/20 | 0.31 |
| ▸ | RARA | P10276 | 1/20 | 0.31 |
| ▸ | RARB | P10826 | 1/20 | 0.31 |
| ▸ | RARG | P13631 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8361917 | 1.00 | TACR1 (0.36) | TACR1GPBAR1RXRARXRBRXRG | |
| Hydrochloric Acid SCHEMBL8361840 | 0.96 | TACR1 (0.33) | TACR1GPBAR1RXRARXRBMEN1 | |
| Hydrochloric Acid SCHEMBL8364314 | 0.90 | RXRB (0.33) | RXRARXRBRXRG | |
| Hydrochloric Acid SCHEMBL8364165 | 0.87 | LMNA (0.32) | — | |
| Hydrochloric Acid SCHEMBL8364768 | 0.86 | TACR1 (0.35) | TACR1GPBAR1RXRARXRBRXRG | |
| Hydrochloric Acid SCHEMBL8366096 | 0.86 | TACR1 (0.35) | TACR1GPBAR1RXRARXRBRXRG | |
| Hydrochloric Acid SCHEMBL8364207 | 0.82 | TACR1 (0.33) | TACR1GPBAR1RXRARXRBMEN1 | |
| Hydrochloric Acid SCHEMBL6927237 | 0.79 | TACR1 (0.34) | TACR1MEN1CYP1A2POLBCYP2C9 | |
| Hydrochloric Acid SCHEMBL6930149 | 0.77 | TACR1 (0.37) | TACR1GPBAR1MEN1CYP1A2POLB | |
| Hydrochloric Acid SCHEMBL6924045 | 0.77 | TACR1 (0.37) | TACR1GPBAR1MEN1CYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999035171-A1 | HIGH-MELTING POLYOLEFIN COPOLYMER ELASTOMERS, CATALYSTS AND METHODS OF SYNTHESIS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JR. UNIVERSITY (US) | 1999-07-15 | — | — | WO | disclosed |