Deferiprone

Deferiprone

SCHEMBL692741

Cc1c(O)c(=O)ccn1C.[Fe]

nearest known ligand 0.96

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.96
CYP2C19 P33261 2/20 0.96
KDM6A O15550 1/20 0.96
KDM4A O75164 1/20 0.96
CYP2C9 P11712 1/20 0.96
KDM5C P41229 1/20 0.96
KDM2B Q8NHM5 1/20 0.96
DOHH Q9BU89 1/20 0.96
KDM2A Q9Y2K7 1/20 0.96
COMT P21964 2/20 0.52
HTT P42858 2/20 0.47
TP53 P04637 1/20 0.47
CYP2D6 P10635 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
APP P05067 3/20 0.41
HRH3 Q9Y5N1 3/20 0.41
LMNA P02545 1/20 0.38
MMP1 P03956 1/20 0.37
MMP7 P09237 1/20 0.37
MMP9 P14780 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Deferiprone SCHEMBL20775057 0.98 KDM4E (1.00) KDM4ECYP2C19KDM6AKDM4ACYP2C9
Deferiprone SCHEMBL94474 0.98 KDM4E (1.00) KDM4ECYP2C19KDM6AKDM4ACYP2C9
Deferiprone SCHEMBL28363784 0.96 KDM4E (0.96) KDM4ECYP2C19KDM6AKDM4ACYP2C9
Deferiprone SCHEMBL10464107 0.96 KDM4E (0.96) KDM4ECYP2C19KDM6AKDM4ACYP2C9
Deferiprone SCHEMBL28536949 0.85 KDM4E (0.76) KDM4ECYP2C19KDM6AKDM4ACYP2C9
Deferiprone SCHEMBL28405012 0.85 KDM4E (0.76) KDM4ECYP2C19KDM6AKDM4ACYP2C9
Deferiprone SCHEMBL6400926 0.85 KDM4E (0.76) KDM4ECYP2C19KDM6AKDM4ACYP2C9
Deferiprone SCHEMBL7224598 0.80 KDM4E (0.67) KDM4ECYP2C19KDM6AKDM4ACYP2C9
Deferiprone SCHEMBL4951162 0.79 KDM4E (0.65) KDM4ECYP2C19KDM6AKDM4ACYP2C9
Deferiprone SCHEMBL9075381 0.78 KDM4E (0.63) KDM4ECYP2C19KDM6AKDM4ACYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 102 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101102762-A Compositions including iron DRUGTECH CORP (US) 2008-01-09 CN claimed
EP-1827419-A2 METHODS AND COMPOSITIONS FOR ENHANCING IRON ABSORPTION Drugtech Corporation (US) 2007-09-05 EP claimed
EP-1827418-A2 COMPOSITIONS INCLUDING IRON Drugtech Corporation (US) 2007-09-05 EP claimed
WO-2006068697-A2 COMPOSITIONS INCLUDING IRON DRUGTECH CORPORATION (US) 2006-06-29 WO claimed
WO-2006068729-A2 METHODS AND COMPOSITIONS FOR ENHANCING IRON ABSORPTION DRUGTECH CORPORATION (US) 2006-06-29 WO claimed
US-20060134227-A1 Compositions including iron DRUGTECH CORPORATION 2006-06-22 US claimed
WO-2003086321-A2 MODIFIED RELEASE MINERALS DRUGTECH CORPORATION (US) 2003-10-23 WO claimed
US-20030190355-A1 Modified release minerals DRUGTECH CORPORATION 2003-10-09 US claimed
WO-2023119230-A1 COAGULATION PATHWAY AND NICOTINAMIDE-ADENINE DINUCLEOTIDE PATHWAY MODULATING COMPOSITIONS AND METHODS OF THEIR USE L'OREAL (FR) 2023-06-29 WO disclosed
US-20220160830-A1 COMPOSITIONS COMPRISING CHOLINE JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT 2022-05-26 US disclosed
CN-114073772-A Use of an iron chelator for the treatment or prevention of polyoma viral infections 上海市公共卫生临床中心 2022-02-22 CN disclosed
US-20210179695-A1 NOVEL FUNGAL TOXINS AND METHODS RELATED TO THE SAME LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER 2021-06-17 US disclosed
CN-112672786-A Hinokitiol analogue, preparation method and pharmaceutical composition thereof 伊利诺伊大学评议会 2021-04-16 CN disclosed
US-10877037-B2 Fungal toxins and methods related to the same LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER (US) 2020-12-29 US disclosed
WO-2006055412-A1 METHODS OF TREATING ERYTHROPOIETIN-RESISTANCE SHIVA BIOMEDICAL, LLC (US) 2006-05-26 WO disclosed
WO-2005120524-A2 NUTRITIONAL FORMULATIONS DRUGTECH CORPORATION (US) 2005-12-22 WO disclosed
US-20050037065-A1 NUTRITIONAL FORMULATIONS DRUGTECH CORPORATION (US) 2005-02-17 US disclosed
WO-2003086321-A2 MODIFIED RELEASE MINERALS DRUGTECH CORPORATION (US) 2003-10-23 WO disclosed
US-20030190355-A1 Modified release minerals DRUGTECH CORPORATION 2003-10-09 US disclosed
US-5051523-A Transcomplexing a complex of a beta-dicarbonyl metal with a chelating agent CIBA-GEIGY CORPORATION (US) 1991-09-24 US disclosed