Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Deferiprone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.76 |
| ▸ | KDM6A | O15550 | 1/20 | 0.76 |
| ▸ | KDM4A | O75164 | 1/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.76 |
| ▸ | KDM5C | P41229 | 1/20 | 0.76 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.76 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.76 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.76 |
| ▸ | COMT | P21964 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Deferiprone SCHEMBL20775057 | 0.87 | KDM4E (1.00) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| Deferiprone SCHEMBL94474 | 0.87 | KDM4E (1.00) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| Deferiprone SCHEMBL28363784 | 0.85 | KDM4E (0.96) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| Deferiprone SCHEMBL692741 | 0.85 | KDM4E (0.96) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| Deferiprone SCHEMBL28536949 | 0.83 | KDM4E (0.76) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| SCHEMBL31748399 | 0.71 | KDM4E (0.57) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| SCHEMBL9700190 | 0.70 | KDM4E (0.56) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| Deferiprone SCHEMBL4951162 | 0.70 | KDM4E (0.65) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| SCHEMBL20382957 | 0.68 | KDM4E (0.54) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| SCHEMBL6995058 | 0.67 | KDM4E (0.62) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111226839-B | Method for breeding hypoxia-resistant hybrid pelteobagrus fulvidraco | 中国水产科学研究院淡水渔业研究中心 | 2021-10-19 | — | — | CN | claimed |
| CN-111226839-A | Method for breeding hypoxia-resistant hybrid pelteobagrus fulvidraco | 中国水产科学研究院淡水渔业研究中心 | 2020-06-05 | — | — | CN | claimed |
| CN-111226839-B | Method for breeding hypoxia-resistant hybrid pelteobagrus fulvidraco | 中国水产科学研究院淡水渔业研究中心 | 2021-10-19 | — | — | CN | disclosed |
| CN-111226839-A | Method for breeding hypoxia-resistant hybrid pelteobagrus fulvidraco | 中国水产科学研究院淡水渔业研究中心 | 2020-06-05 | — | — | CN | disclosed |