Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | GFER | P55789 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11772616 | 0.84 | ALDH1A1 (0.60) | ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL31252538 | 0.84 | ALDH1A1 (0.60) | ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL11049245 | 0.83 | PADI4 (0.45) | HPGDKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL6925963 | 0.82 | ALDH1A1 (0.61) | HPGDKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL4638446 | 0.81 | NPC1 (0.51) | HPGDKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL6929315 | 0.76 | KDM4E (0.69) | HPGDKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL12939133 | 0.76 | F2 (0.61) | HPGDKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL4816763 | 0.74 | PTGS2 (0.74) | HPGDKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL28171931 | 0.73 | HPGD (0.51) | HPGDKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL10937675 | 0.73 | HPGD (0.53) | HPGDKDM4EALDH1A1HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518273-B1 | 2-aryl indole derivative as antagonists of tachykinins | MERCK SHARP & DOHME LTD. | 2003-02-11 | — | — | US | disclosed |