Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | LMNA | P02545 | 5/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TACR2 | P21452 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6929884 | 0.90 | ALDH1A1 (0.57) | ALDH1A1LMNACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL26654775 | 0.87 | ALDH1A1 (0.61) | ALDH1A1LMNACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL4319388 | 0.87 | ALDH1A1 (0.54) | ALDH1A1LMNACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL4643645 | 0.86 | CTSV (0.57) | ALDH1A1LMNACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1508495 | 0.82 | VCAM1 (0.57) | ALDH1A1LMNACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL6234734 | 0.81 | ALDH1A1 (0.48) | ALDH1A1LMNACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL662081 | 0.80 | ALDH1A1 (0.57) | ALDH1A1LMNACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL13220970 | 0.80 | ALDH1A1 (0.70) | ALDH1A1LMNACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL19332171 | 0.78 | ALDH1A1 (0.54) | ALDH1A1LMNACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9153926 | 0.78 | ALDH1A1 (0.58) | ALDH1A1LMNACYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| CN-1321153-A | telomerase inhibitors and methods of use thereof | GERON CORP (US) | 2001-11-07 | — | — | CN | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |