Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.47 |
| ▸ | FLT1 | P17948 | 5/20 | 0.39 |
| ▸ | RET | P07949 | 4/20 | 0.39 |
| ▸ | PLK4 | O00444 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.39 |
| ▸ | LCK | P06239 | 3/20 | 0.39 |
| ▸ | LYN | P07948 | 3/20 | 0.39 |
| ▸ | FLT4 | P35916 | 3/20 | 0.39 |
| ▸ | FLT3 | P36888 | 3/20 | 0.39 |
| ▸ | FRK | P42685 | 3/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.39 |
| ▸ | BLK | P51451 | 3/20 | 0.39 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.39 |
| ▸ | NEK2 | P51955 | 3/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.39 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.39 |
| ▸ | STK3 | Q13188 | 3/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3126763 | 0.76 | KDR (0.50) | KDRFLT1RETPLK4ROCK2 | |
| SCHEMBL22659243 | 0.72 | KDR (0.46) | KDRFLT1RETPLK4ROCK2 | |
| SCHEMBL10120016 | 0.71 | LIMK1 (0.37) | KDRRETPLK4ROCK2MAP4K4 | |
| SCHEMBL6926826 | 0.70 | NOS3 (0.33) | KDRABL1SRCPI4KBPIK3CD | |
| SCHEMBL6926808 | 0.69 | NOS3 (0.36) | KDM4EALDH1A1HPGDMAPK1HSD17B10 | |
| SCHEMBL6928039 | 0.68 | MET (0.33) | RETMET | |
| SCHEMBL3120400 | 0.66 | KDR (0.71) | KDRFLT1RETPLK4ROCK2 | |
| SCHEMBL2976034 | 0.66 | KDR (0.67) | KDRFLT1RETPLK4ROCK2 | |
| SCHEMBL10198718 | 0.66 | IRAK4 (0.48) | RETMAP4K4IRAK1LIMK1MAP4K2 | |
| SCHEMBL6925166 | 0.65 | P2RX3 (0.38) | KDRRETCLK4CSNK1A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130018038-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2013-01-17 | — | — | US | disclosed |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-03-29 | — | — | US | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018038-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | KDR 3297/4885FLT1 1094/4885RET 2772/4885 |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | KDR 3297/4885FLT1 1094/4885RET 2772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.