Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | YAP1 | P46937 | 2/20 | 0.51 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.50 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2883449 | 0.88 | GPR119 (0.58) | GPR119MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL27380046 | 0.88 | YAP1 (0.54) | GPR119KDM4EYAP1HPGDHTT | |
| SCHEMBL4927184 | 0.87 | GPR119 (0.54) | GPR119NPSR1ACHEYAP1TLR9 | |
| SCHEMBL20510744 | 0.86 | GPR119 (0.48) | GPR119YAP1GRM5 | |
| SCHEMBL6263583 | 0.86 | GPR119 (0.61) | GPR119ACHEYAP1TLR9TLR7 | |
| SCHEMBL27379977 | 0.86 | GPR119 (0.45) | GPR119MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL2195644 | 0.85 | FAAH (0.65) | MAPTKDM4EALDH1A1LMNAKMT2A | |
| SCHEMBL11889863 | 0.85 | MAPT (0.65) | MAPTKDM4EALDH1A1LMNANPSR1 | |
| SCHEMBL17658994 | 0.84 | GPR119 (0.54) | GPR119ACHEYAP1TLR9TLR7 | |
| SCHEMBL5235873 | 0.84 | GPR119 (0.54) | GPR119MAPTKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054956-A1 | HETEROBIFUNCTIONAL COMPOUNDS AND METHODS OF TREATING DISEASE | HALDA THERAPEUTICS OPCO, INC. (US) | 2024-03-14 | — | — | WO | disclosed |
| US-6518273-B1 | 2-aryl indole derivative as antagonists of tachykinins | MERCK SHARP & DOHME LTD. | 2003-02-11 | — | — | US | disclosed |
| WO-2000051984-A1 | 2-ARYL INDOLE DERIVATIVES AS ANTAGONISTS OF TACHYKININS | MERCK SHARP & DOHME LIMITED (GB) | 2000-09-08 | — | — | WO | disclosed |