Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.32 |
| ▸ | G6PD | P11413 | 1/20 | 0.31 |
| ▸ | IDE | P14735 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16288940 | 0.74 | DAO (0.40) | SMN1; SMN2ENPP2PTGS2G6PDIDE | |
| SCHEMBL3464973 | 0.73 | ENPP2 (0.33) | SMN1; SMN2ENPP2PTGS2G6PDIDE | |
| SCHEMBL2652744 | 0.73 | PTGS2 (0.39) | SMN1; SMN2ENPP2PTGS2G6PDIDE | |
| SCHEMBL25207147 | 0.71 | ENPP2 (0.37) | ENPP2PTGS2PTGS1 | |
| SCHEMBL15881134 | 0.70 | CA2 (0.39) | ENPP2PTGS2CA2 | |
| SCHEMBL7892535 | 0.68 | DAO (0.53) | — | |
| SCHEMBL3126304 | 0.68 | LOX (0.51) | — | |
| Hydrochloric Acid SCHEMBL28047351 | 0.68 | CA2 (0.38) | ENPP2CA2 | |
| SCHEMBL3126299 | 0.67 | KMT2A (0.52) | — | |
| SCHEMBL7886041 | 0.67 | KMT2A (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401446-A1 | TETRAHYDROQUINOLIN DERIVATIVES FOR THE INHIBITION OF DISEASES ASSOCIATED WITH ESTROGEN DEPRIVATION OR WITH AN ABERRANT PHYSIOLOGICAL RESPONSE TO ENDOGENOUS ESTROGEN | ELI LILLY AND COMPANY (US) | 2004-03-31 | — | — | EP | claimed |
| WO-2002094268-A1 | TETRAHYDROQUINOLIN DERIVATIVES FOR THE INHIBITION OF DISEASES ASSOCIATED WITH ESTROGEN DEPRIVATION OR WITH AN ABERRANT PHYSIOLOGICAL RESPONSE TO ENDOGENOUS ESTROGEN | ELI LILLY AND COMPANY (US) | 2002-11-28 | — | — | WO | claimed |
| WO-2004103981-A1 | PROCESS FOR PREPARING A 4,7-BIS(5-HALOTHIEN-2-YL)-2,1,3-BENZOTHIADIAZOLE AND A PRECURSOR THEREFOR | DOW GLOBAL TECHNOLOGIES INC. (US) | 2004-12-02 | — | — | WO | disclosed |