Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 4/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.40 |
| ▸ | LATS1 | O95835 | 3/20 | 0.40 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | EIF4EBP1 | Q13541 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6927584 | 0.88 | HDAC6 (0.43) | HDAC6KDM4EALOX15TSHRTDP1 | |
| SCHEMBL29571733 | 0.80 | HDAC6 (0.64) | HDAC6KDM4EALOX15TSHRTDP1 | |
| SCHEMBL1161498 | 0.80 | HDAC6 (0.64) | HDAC6KDM4EALOX15TSHRTDP1 | |
| SCHEMBL31330665 | 0.78 | IDO1 (0.48) | KDM4EIDO1KDM4CLATS1 | |
| SCHEMBL2045483 | 0.75 | ALDH1A1 (0.46) | HDAC6KDM4EALOX15TSHRTDP1 | |
| SCHEMBL13789540 | 0.73 | L3MBTL1 (0.61) | TSHRL3MBTL1IDO1LMNA | |
| SCHEMBL1161537 | 0.72 | CYP3A4 (0.55) | HDAC6KDM4EALOX15TSHRTDP1 | |
| SCHEMBL14473822 | 0.72 | HIF1A (0.57) | TSHRL3MBTL1IDO1KDM4CLMNA | |
| SCHEMBL6930783 | 0.71 | PDE4A (0.49) | HDAC6KDM4EALOX15TSHRTDP1 | |
| SCHEMBL3321587 | 0.71 | ALDH1A1 (0.49) | KDM4ETDP1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011012622-A1 | BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF GLYTL MEDIATED DISORDERS | GLAXO GROUP LIMITED (GB) | 2011-02-03 | — | — | WO | disclosed |