Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PPID | Q08752 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6929499 | 0.88 | L3MBTL1 (0.47) | L3MBTL1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL11704881 | 0.81 | ALDH1A1 (0.40) | L3MBTL1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6784721 | 0.81 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1MEN1KMT2APKM | |
| SCHEMBL7378376 | 0.77 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL24739415 | 0.74 | L3MBTL1 (0.44) | L3MBTL1ALDH1A1ALOX5SMN1; SMN2PPID | |
| SCHEMBL11704885 | 0.73 | ALDH1A1 (0.39) | L3MBTL1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8023959 | 0.72 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2A | |
| SCHEMBL11423209 | 0.72 | TDP1 (0.38) | L3MBTL1ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL685365 | 0.72 | L3MBTL1 (0.59) | L3MBTL1ALDH1A1KDM4ETDP1PPID | |
| SCHEMBL17737107 | 0.72 | L3MBTL1 (0.59) | L3MBTL1ALDH1A1KDM4ETDP1PPID |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242074-A4 | 5-BENZYL-OCTAHYDROINDOLE AND 6-BENZYL-DECAHYDROQUINOLINE NMDA/NR2B ANTAGONISTS | MERCK & CO INC (US) | 2003-01-29 | — | — | EP | disclosed |
| EP-1242074-A1 | 5-BENZYL-OCTAHYDROINDOLE AND 6-BENZYL-DECAHYDROQUINOLINE NMDA/NR2B ANTAGONISTS | Merck & Co., Inc. (US) | 2002-09-25 | — | — | EP | disclosed |
| US-6369076-B1 | ANALGESICS | MERCK & CO. INC. | 2002-04-09 | — | — | US | disclosed |
| WO-2001032171-A1 | 5-BENZYL-OCTAHYDROINDOLE AND 6-BENZYL-DECAHYDROQUINOLINE NMDA/NR2B ANTAGONISTS | MERCK & CO., INC. (US) | 2001-05-10 | — | — | WO | disclosed |