SCHEMBL6929631

SCHEMBL6929631

Cc1cccc(C(=O)O)c1NC(=O)OCc1ccccc1

nearest known ligand 0.63

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.63
RAB9A P51151 1/20 0.63
CASP3 P42574 2/20 0.61
SMN1; SMN2 Q16637 2/20 0.53
POLB P06746 3/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
LMNA P02545 1/20 0.52
ALDH1A1 P00352 2/20 0.51
MGLL Q99685 1/20 0.50
MAOA P21397 1/20 0.49
KDM4E B2RXH2 1/20 0.49
NLRP3 Q96P20 1/20 0.49
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2D6 P10635 1/20 0.48
CYP2C9 P11712 1/20 0.48
TSHR P16473 1/20 0.48
CYP2C19 P33261 1/20 0.48
HSD17B10 Q99714 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1095326 0.85 NLRP3 (0.61) NPC1RAB9ASMN1; SMN2POLBLMNA
SCHEMBL7229249 0.84 NPC1 (0.65) NPC1RAB9ACASP3SMN1; SMN2POLB
SCHEMBL6931240 0.83 P2RX7 (0.54) NPC1RAB9ASMN1; SMN2POLBLMNA
SCHEMBL29956120 0.81 NPC1 (0.60) NPC1RAB9ACASP3SMN1; SMN2POLB
SCHEMBL2233522 0.79 NPC1 (0.69) NPC1RAB9ACASP3SMN1; SMN2POLB
SCHEMBL28564954 0.78 NPC1 (0.64) NPC1RAB9ACASP3SMN1; SMN2POLB
SCHEMBL4955341 0.78 NLRP3 (0.47) NPC1RAB9ACASP3POLBLMNA
SCHEMBL5853278 0.78 NPC1 (1.00) NPC1RAB9ACASP3SMN1; SMN2POLB
SCHEMBL10489837 0.78 NPC1 (0.76) NPC1RAB9ACASP3SMN1; SMN2POLB
SCHEMBL3212368 0.77 EPHX2 (0.57) CASP3POLBLMNAKDM4ENLRP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0801640-B1 2,5-DIAMINO-3,4-DISUBSTITUTED-1,6-DIPHENYLHEXANE ISOSTERES COMPRISING BENZAMIDE, SULFONAMIDE AND ANTHRANILAMIDE SUBUNITS AND METHODS OF USING SAME USA (US) 2003-03-26 EP disclosed
US-6066656-A IN VITRO METHOD OF ASSAYING FOR ANTIRETROVIRAL ACTIVITY OF A COMPOUND BY MEASURING THE FLUORESCENCE OF A FLUORESCENT COMPOUND, MEASURING THE CHANGE IN FLUORESCENCE OF SAID COMPOUND IN THE PRESENCE OF A RETROVIRAL PROTEASE THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2000-05-23 US disclosed
US-5925780-A VIRICIDES FOR RETROVIRAL SPECIES THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1999-07-20 US disclosed
US-5728718-A RETROVIRAL PROTEASE INHIBITOR; TREATMENT OF HTLV THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1998-03-17 US disclosed
EP-0801640-A1 2,5-DIAMINO-3,4-DISUBSTITUTED-1,6-DIPHENYLHEXANE ISOSTERES COMPRISING BENZAMIDE, SULFONAMIDE AND ANTHRANILAMIDE SUBUNITS AND METHODS OF USING SAME THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services (US) 1997-10-22 EP disclosed
WO-1996019437-A9 2,5-DIAMINO-3,4-DISUBSTITUTED-1,6-DIPHENYLHEXANE ISOSTERES COMPRISING BENZAMIDE, SULFONAMIDE AND ANTHRANILAMIDE SUBUNITS AND METHODS OF USING SAME 1996-09-06 WO disclosed
WO-1996019437-A1 2,5-DIAMINO-3,4-DISUBSTITUTED-1,6-DIPHENYLHEXANE ISOSTERES COMPRISING BENZAMIDE, SULFONAMIDE AND ANTHRANILAMIDE SUBUNITS AND METHODS OF USING SAME THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1996-06-27 WO disclosed