Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.69 |
| ▸ | RAB9A | P51151 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | CFD | P00746 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.54 |
| ▸ | MGLL | Q99685 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5055502 | 0.91 | NPC1 (0.58) | NPC1RAB9AALDH1A1CFDMGLL | |
| SCHEMBL8115672 | 0.90 | ALDH1A1 (0.63) | NPC1RAB9AALDH1A1CFDPOLB | |
| SCHEMBL22497489 | 0.90 | KDM4E (0.61) | NPC1RAB9AALDH1A1CFDPOLB | |
| SCHEMBL6190439 | 0.87 | NPC1 (0.66) | NPC1RAB9AALDH1A1POLBCASP3 | |
| SCHEMBL8894000 | 0.87 | NPC1 (0.58) | NPC1RAB9AALDH1A1CFDPOLB | |
| SCHEMBL5055467 | 0.86 | NPC1 (0.57) | NPC1RAB9AALDH1A1CFDPOLB | |
| SCHEMBL22497537 | 0.86 | TRPV1 (0.58) | NPC1RAB9AALDH1A1POLBMGLL | |
| SCHEMBL10875637 | 0.86 | MGLL (0.55) | NPC1RAB9AALDH1A1CFDPOLB | |
| SCHEMBL10874779 | 0.86 | NPC1 (0.68) | NPC1RAB9AALDH1A1POLBL3MBTL1 | |
| SCHEMBL22497553 | 0.85 | RAB9A (0.52) | NPC1RAB9AALDH1A1CFDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4873232-A | ARTHRITIS AND AUTOIMMUNE DISEASES | SYNTEX (US) | 1989-10-10 | — | — | US | claimed |
| US-20230265104-A1 | NOVEL HETEROCYCLIC COMPOUNDS | Prism BioLab Co., Ltd. (JP) | 2023-08-24 | — | — | US | disclosed |
| CN-111763164-A | Preparation method and application of ortho-carbonyl amino substituted benzene derivatives | 中国医学科学院药物研究所 | 2020-10-13 | — | — | CN | disclosed |
| WO-2020199945-A1 | ORTHO-CARBONYL AMINO-SUBSTITUTED BENZENE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 中国医学科学院药物研究所 | 2020-10-08 | — | — | WO | disclosed |
| WO-2020199945-A1 | ORTHO-CARBONYL AMINO-SUBSTITUTED BENZENE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 中国医学科学院药物研究所 | 2020-10-08 | — | — | WO | disclosed |
| US-10254291-B2 | Quaternary ammonium containing isobaric tag for quantitative glycan profiling | UNIVERSITY OF MARYLAND, COLLEGE PARK (US) | 2019-04-09 | — | — | US | disclosed |
| US-10254291-B2 | Quaternary ammonium containing isobaric tag for quantitative glycan profiling | UNIVERSITY OF MARYLAND, COLLEGE PARK (US) | 2019-04-09 | — | — | US | disclosed |
| US-20160252518-A1 | QUATERNARY AMINE CONTAINING ISOBARIC TAG FOR QUANTITATIVE GLYCAN PROFILING | THE JOHNS HOPKINS UNIVERSITY | 2016-09-01 | — | — | US | disclosed |
| US-20160252518-A1 | QUATERNARY AMINE CONTAINING ISOBARIC TAG FOR QUANTITATIVE GLYCAN PROFILING | THE JOHNS HOPKINS UNIVERSITY | 2016-09-01 | — | — | US | disclosed |
| US-20160252518-A1 | QUATERNARY AMINE CONTAINING ISOBARIC TAG FOR QUANTITATIVE GLYCAN PROFILING | THE JOHNS HOPKINS UNIVERSITY | 2016-09-01 | — | — | US | disclosed |
| US-6620782-B1 | Substituted 2-aminobenzamide caspase inhibitors and the use thereof | CYTOVIA, INC. | 2003-09-16 | — | — | US | disclosed |
| US-6620782-B1 | Substituted 2-aminobenzamide caspase inhibitors and the use thereof | CYTOVIA, INC. | 2003-09-16 | — | — | US | disclosed |
| US-5945325-A | MUTANT ENZYME WITH SPECIFIC AMINO ACID SUBSTITUTIONS ISOLATED FROM LIBRARY; FOR DEBLOCKING, DEPROTECTING BETA-LACTAM ANTIBIOTICS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1999-08-31 | — | — | US | disclosed |
| US-5906930-A | NUCLEIC ACID CODING FOR MUTANT ENZYME; FOR REMOVAL OF CARBOXY ACID PROTECTING GROUPS DURING SYNTHESIS OF ANTIBIOTICS LIKE LORACARBEF | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1999-05-25 | — | — | US | disclosed |
| EP-0876490-A1 | PARA-NITROBENZYL ESTERASES WITH ENHANCED ACTIVITY IN AQUEOUS AND NONAQUEOUS MEDIA | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1998-11-11 | — | — | EP | disclosed |
| US-5741691-A | Para-nitrobenzyl esterases with enhanced activity in aqueous and nonaqueous media | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1998-04-21 | — | — | US | disclosed |
| WO-1997027304-A9 | PARA-NITROBENZYL ESTERASES WITH ENHANCED ACTIVITY IN AQUEOUS AND NONAQUEOUS MEDIA | — | 1997-10-09 | — | — | WO | disclosed |
| WO-1997027304-A1 | PARA-NITROBENZYL ESTERASES WITH ENHANCED ACTIVITY IN AQUEOUS AND NONAQUEOUS MEDIA | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1997-07-31 | — | — | WO | disclosed |
| US-4873232-A | ARTHRITIS AND AUTOIMMUNE DISEASES | SYNTEX (US) | 1989-10-10 | — | — | US | disclosed |
| EP-0206323-A1 | 2-Oxy-4H-3,1-benzoxazin-4-one derivatives and related compounds | SYNTEX (U.S.A.) INC. (US) | 1986-12-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265104-A1 | NOVEL HETEROCYCLIC COMPOUNDS | MKI67, CCNI, KRAS | NPC1 761/4885RAB9A 688/4885ALDH1A1 345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.