Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.48 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.48 |
| ▸ | SLC10A6 | Q3KNW5 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | PIM1 | P11309 | 5/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6929933 | 0.87 | KMT2A (0.51) | MEN1KMT2ASMN1; SMN2ALDH1A1PIM1 | |
| SCHEMBL6929936 | 0.87 | KMT2A (0.51) | MEN1KMT2ASMN1; SMN2ALDH1A1PIM1 | |
| SCHEMBL6927181 | 0.79 | MEN1 (0.52) | MEN1KMT2ASMN1; SMN2PIM1PIM2 | |
| SCHEMBL6927180 | 0.79 | MEN1 (0.52) | MEN1KMT2ASMN1; SMN2PIM1PIM2 | |
| SCHEMBL6927087 | 0.79 | NAMPT (0.51) | MEN1KMT2ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL6927082 | 0.79 | NAMPT (0.51) | MEN1KMT2ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL6926883 | 0.79 | AKR1B1 (0.53) | PIM1PIM2PIM3AKR1B1HDAC4 | |
| SCHEMBL6928703 | 0.77 | PIM1 (0.55) | HPGDPIM1PIM2PIM3AKR1B1 | |
| SCHEMBL6928700 | 0.77 | PIM1 (0.55) | HPGDPIM1PIM2PIM3AKR1B1 | |
| SCHEMBL6928941 | 0.77 | AKR1B1 (0.48) | PIM1PIM2PIM3AKR1B1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |