Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | TPMT | P51580 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24165077 | 0.85 | HSD17B10 (0.51) | HSD17B10TDP1MAPTALDH1A1KDM4E | |
| SCHEMBL6215179 | 0.85 | HSD17B10 (0.55) | HSD17B10TDP1MAPTALDH1A1KDM4E | |
| SCHEMBL421547 | 0.81 | MAPT (0.51) | HSD17B10TDP1MAPTALDH1A1KDM4E | |
| SCHEMBL22245019 | 0.81 | TDP1 (0.56) | HSD17B10TDP1MAPTALDH1A1KDM4E | |
| SCHEMBL1987207 | 0.81 | HSD17B10 (0.51) | HSD17B10TDP1MAPTALDH1A1KDM4E | |
| SCHEMBL30316357 | 0.80 | HSD17B10 (0.50) | HSD17B10TDP1MAPTALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL422457 | 0.80 | MAPT (0.50) | HSD17B10TDP1MAPTALDH1A1KDM4E | |
| SCHEMBL1505827 | 0.80 | TDP1 (0.61) | HSD17B10TDP1MAPTALDH1A1KDM4E | |
| SCHEMBL7127616 | 0.79 | HSD17B10 (0.53) | HSD17B10TDP1MAPTALDH1A1KDM4E | |
| SCHEMBL4995728 | 0.79 | TDP1 (0.49) | HSD17B10TDP1MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100486-A4 | MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-01-15 | — | — | EP | disclosed |
| EP-1100486-A1 | MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000006147-A1 | MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |