Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | TPMT | P51580 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.40 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SELL | P14151 | 1/20 | 0.39 |
| ▸ | SELP | P16109 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6215179 | 0.85 | HSD17B10 (0.55) | TDP1MAPTHSD17B10TPMTLCK | |
| SCHEMBL6930173 | 0.81 | HSD17B10 (0.51) | TDP1MAPTHSD17B10TPMTLCK | |
| SCHEMBL1987207 | 0.81 | HSD17B10 (0.51) | TDP1MAPTHSD17B10TPMTLCK | |
| SCHEMBL1438720 | 0.81 | TDP1 (0.59) | TDP1MAPTHSD17B10TPMTALDH1A1 | |
| SCHEMBL30316357 | 0.80 | HSD17B10 (0.50) | TDP1MAPTHSD17B10TPMTLCK | |
| SCHEMBL1505827 | 0.80 | TDP1 (0.61) | TDP1MAPTHSD17B10LCKFYN | |
| SCHEMBL28841565 | 0.79 | TDP1 (0.58) | TDP1MAPTHSD17B10ALDH1A1KDM4E | |
| SCHEMBL7127616 | 0.79 | HSD17B10 (0.53) | TDP1MAPTHSD17B10TPMTLCK | |
| SCHEMBL11026756 | 0.79 | MAPT (0.73) | TDP1MAPTHSD17B10TPMTLCK | |
| SCHEMBL24165077 | 0.78 | HSD17B10 (0.51) | TDP1MAPTHSD17B10TPMTLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020148354-A1 | SUBSTITUTED CHROMEN-4-ONE FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2020-07-23 | — | — | WO | disclosed |