Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.43 |
| ▸ | GRB2 | P62993 | 1/20 | 0.43 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.42 |
| ▸ | ACE | P12821 | 2/20 | 0.40 |
| ▸ | NMUR2 | Q9GZQ4 | 1/20 | 0.39 |
| ▸ | NMUR1 | Q9HB89 | 1/20 | 0.39 |
| ▸ | NRP1 | O14786 | 1/20 | 0.39 |
| ▸ | RAMP3 | O60896 | 3/20 | 0.38 |
| ▸ | CALCR | P30988 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874280 | 0.87 | EPHA2 (0.43) | OPRM1OPRK1EPHA2ACENMUR2 | |
| SCHEMBL31034448 | 0.87 | NRP1 (0.46) | OPRM1OPRK1GRB2EPHA2NRP1 | |
| SCHEMBL31412169 | 0.85 | OPRM1 (0.46) | OPRM1OPRK1GRB2EPHA2NMUR2 | |
| SCHEMBL3242151 | 0.84 | OPRM1 (0.40) | OPRM1OPRK1EPHA2 | |
| SCHEMBL30416412 | 0.83 | GRB2 (0.47) | OPRM1OPRK1GRB2EPHA2NMUR2 | |
| SCHEMBL24485494 | 0.83 | GRB2 (0.49) | OPRM1OPRK1GRB2EPHA2NMUR2 | |
| SCHEMBL20694547 | 0.82 | NRP1 (0.46) | OPRM1OPRK1GRB2EPHA2NRP1 | |
| SCHEMBL8377689 | 0.81 | ACE (0.47) | OPRM1OPRK1GRB2EPHA2ACE | |
| SCHEMBL29391363 | 0.81 | GRB2 (0.55) | OPRM1OPRK1GRB2EPHA2NMUR2 | |
| SCHEMBL31313193 | 0.81 | RAMP3 (0.47) | GRB2EPHA2RAMP3CALCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073449-A4 | AMINO ACID AMIDINOHYDRAZONES, ALKOXYGUANIDINES AND AMINOGUANIDINES AS PROTEASE INHIBITORS | DIMENSIONAL PHARM INC (US) | 2003-01-02 | — | — | EP | disclosed |
| EP-1086122-A1 | PYRAZINONE PROTEASE INHIBITORS | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (US) | 2001-03-28 | — | — | EP | disclosed |
| EP-1073449-A1 | AMINO ACID AMIDINOHYDRAZONES, ALKOXYGUANIDINES AND AMINOGUANIDINES AS PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999064446-A1 | PYRAZINONE PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1999-12-16 | — | — | WO | disclosed |
| WO-1999055355-A1 | AMINO ACID AMIDINOHYDRAZONES, ALKOXYGUANIDINES AND AMINOGUANIDINES AS PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1999-11-04 | — | — | WO | disclosed |