SCHEMBL6930359

SCHEMBL6930359

S=C(Oc1ccccc1Cl)c1c2ccccc2nc2ccccc12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.43
MAOB P27338 1/20 0.43
MAPT P10636 5/20 0.41
HTT P42858 2/20 0.41
KMT2A Q03164 3/20 0.40
ALDH1A1 P00352 5/20 0.40
POLB P06746 2/20 0.40
MEN1 O00255 2/20 0.38
KDM4E B2RXH2 3/20 0.36
GLA P06280 2/20 0.36
TDP1 Q9NUW8 2/20 0.36
GAA P10253 1/20 0.36
MAPK1 P28482 1/20 0.36
CLK1 P49759 1/20 0.36
CDK9 P50750 1/20 0.36
CDK5 Q00535 1/20 0.36
DYRK1A Q13627 1/20 0.36
DYRK2 Q92630 1/20 0.36
CLK4 Q9HAZ1 1/20 0.36
DYRK1B Q9Y463 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7755746 0.84 MAOA (0.43) MAOAMAOBMAPTHTTKMT2A
SCHEMBL8333201 0.81 POLB (0.52) MAPTALDH1A1POLBKDM4ETDP1
SCHEMBL7756511 0.78 KDM4E (0.48) MAOAMAOBMAPTHTTKMT2A
SCHEMBL6931307 0.78 MAPT (0.43) MAOAMAOBMAPTHTTKMT2A
SCHEMBL8581655 0.78 PDE10A (0.41) MAPTHTTKMT2AALDH1A1POLB
SCHEMBL8740694 0.78 MAPT (0.41) MAPTKMT2AALDH1A1POLBMEN1
SCHEMBL7030411 0.75 SCN9A (0.43) MAPTHTTKMT2AALDH1A1MEN1
SCHEMBL7024083 0.72 POLB (0.43) MAPTKMT2AALDH1A1POLBMEN1
SCHEMBL7027183 0.72 POLB (0.51) MAPTHTTKMT2AALDH1A1POLB
SCHEMBL8875052 0.72 NPSR1 (0.47) MAPTHTTKMT2AALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1054933-A4 CHEMILUMINESCENT REACTIONS USING DIHYDROXYAROMATIC COMPOUNDS AND HETEROCYCLIC ENOL PHOSPHATES LUMIGEN INC (US) 2003-07-09 EP disclosed
EP-1054933-A1 CHEMILUMINESCENT REACTIONS USING DIHYDROXYAROMATIC COMPOUNDS AND HETEROCYCLIC ENOL PHOSPHATES LUMIGEN, INC. (US) 2000-11-29 EP disclosed
WO-1999040161-A1 CHEMILUMINESCENT REACTIONS USING DIHYDROXYAROMATIC COMPOUNDS AND HETEROCYCLIC ENOL PHOSPHATES LUMIGEN, INC. (US) 1999-08-12 WO disclosed
EP-0819119-A4 COMPOUNDS, COMPOSITIONS AND METHODS FOR GENERATING CHEMILUMINESCENCE WITH PHOSPHATASE ENZYMES LUMIGEN INC (US) 1999-04-14 EP disclosed
EP-0819119-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR GENERATING CHEMILUMINESCENCE WITH PHOSPHATASE ENZYMES LUMIGEN, INC. (US) 1998-01-21 EP disclosed
WO-1997026245-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR GENERATING CHEMILUMINESCENCE WITH PHOSPHATASE ENZYMES LUMIGEN, INC. (US) 1997-07-24 WO disclosed