Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12647563 | 0.81 | NPC1 (0.48) | NPC1RECQLRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6930571 | 0.81 | NPC1 (0.48) | NPC1RECQLRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL5021240 | 0.73 | NPC1 (0.51) | NPC1RECQLRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1773796 | 0.72 | NPC1 (0.50) | NPC1RECQLRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1773795 | 0.72 | NPC1 (0.50) | NPC1RECQLRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6131580 | 0.72 | CA1 (0.52) | CTSSCTSKMEN1KMT2ATSHR | |
| SCHEMBL3819136 | 0.72 | CTSS (0.54) | NPC1RECQLRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3819131 | 0.72 | CTSS (0.54) | NPC1RECQLRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL13897570 | 0.71 | CTSK (0.50) | NPC1RECQLRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1754171 | 0.70 | SMN1; SMN2 (0.53) | NPC1RECQLRAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354441-B2 | Oxazoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2013-01-15 | — | — | US | disclosed |
| US-20110112080-A1 | OXAZOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112080-A1 | OXAZOLINE DERIVATIVES | TAAR1, HCRTR1, NPY1R | NPC1 785/4885RECQL 1422/4885RAB9A 2356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.