Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 11/20 | 0.46 |
| ▸ | ACHE | P22303 | 11/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29752682 | 0.88 | KDM4E (0.50) | KDM4EMEN1KMT2ABCHEACHE | |
| SCHEMBL11070778 | 0.86 | KDM4E (0.58) | KDM4EMEN1KMT2ABCHEACHE | |
| 1-Ethylquinolonium SCHEMBL11069884 | 0.85 | KDM4E (0.50) | KDM4EMEN1KMT2ABCHEACHE | |
| SCHEMBL11071834 | 0.81 | KDM4E (0.54) | KDM4EMEN1KMT2ABCHEACHE | |
| SCHEMBL146684 | 0.78 | LMNA (0.38) | KDM4EMEN1KMT2A | |
| SCHEMBL4848699 | 0.77 | LMNA (0.45) | KDM4EMEN1KMT2AACHE | |
| SCHEMBL7789448 | 0.76 | BCHE (0.52) | KDM4EMEN1KMT2ABCHEACHE | |
| Water SCHEMBL7556226 | 0.76 | LMNA (0.44) | KDM4EMEN1KMT2AACHE | |
| SCHEMBL4303539 | 0.75 | SMN1; SMN2 (0.40) | KDM4EMEN1KMT2ABCHEACHE | |
| SCHEMBL9808014 | 0.74 | GAA (0.43) | KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051655-A4 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | ISTA PHARMACEUTICALS INC (US) | 2003-03-19 | — | — | EP | disclosed |
| US-20010016731-A1 | Methods and apparatus for accelerated orthokeratology | DEVORE DALE (US) | 2001-08-23 | — | — | US | disclosed |
| US-6161544-A | Methods for accelerated orthokeratology | KERATOFORM, INC. (US) | 2000-12-19 | — | — | US | disclosed |
| EP-1051655-A1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | Ista Pharmaceuticals, Inc. (US) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999039238-A1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | KERATOFORM, INC. (US) | 1999-08-05 | — | — | WO | disclosed |