Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 3/20 | 0.80 |
| ▸ | NOS3 | P29474 | 2/20 | 0.80 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.69 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.69 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.69 |
| ▸ | CA12 | O43570 | 2/20 | 0.67 |
| ▸ | CA1 | P00915 | 2/20 | 0.67 |
| ▸ | CA2 | P00918 | 2/20 | 0.67 |
| ▸ | CA9 | Q16790 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.56 |
| ▸ | F2 | P00734 | 1/20 | 0.56 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.56 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.56 |
| ▸ | SLC22A2 | O15244 | 3/20 | 0.56 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.56 |
| ▸ | SLC22A3 | O75751 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15435836 | 0.82 | NOS1 (0.72) | NOS1NOS3ADRA2AADRA2BADRA2C | |
| SCHEMBL6299889 | 0.82 | ADRA2A (0.75) | NOS1NOS3ADRA2AADRA2BADRA2C | |
| 4-Guanidino-Benzoic Acid SCHEMBL1363882 | 0.80 | CA12 (1.00) | NOS1NOS3ADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL11226185 | 0.80 | NOS1 (0.73) | NOS1NOS3ADRA2AADRA2BADRA2C | |
| SCHEMBL8446419 | 0.78 | NOS1 (0.50) | NOS1NOS3ADRA2AADRA2BADRA2C | |
| 4-Guanidino-Benzoic Acid SCHEMBL20488250 | 0.77 | CA12 (0.92) | NOS1NOS3ADRA2AADRA2BADRA2C | |
| SCHEMBL18806562 | 0.77 | MAPT (0.83) | NOS1NOS3CA1CA2POLB | |
| SCHEMBL29042753 | 0.77 | MAPT (0.83) | NOS1NOS3CA1CA2POLB | |
| SCHEMBL14336603 | 0.77 | MAPT (0.83) | NOS1NOS3CA1CA2POLB | |
| SCHEMBL6930691 | 0.76 | HTR3E (0.56) | NOS1NOS3PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865434-B1 | COMPOUNDS AND THEIR USE TO TREAT INFECTIOUS DISEASES | PICOWER INST MED RES (US) | 2003-12-17 | — | — | EP | claimed |
| US-4347310-A | INCREASED PHOTOSENZITIVITY USING GUANIDINE DERIVTIVES AS SENSITIZERS; PHOTOSTABILITY; STORAGE STABILITY | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1982-08-31 | — | — | US | disclosed |