SCHEMBL6931771

SCHEMBL6931771

CC(C)(C)ON(C=O)[C@@H](Cc1ccccc1)[C@@H](O)[C@@H](O)[C@@H](N)Cc1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC15A1 P46059 1/20 0.39
CSNK1E P49674 1/20 0.36
LTA4H P09960 2/20 0.36
LAP3 P28838 7/20 0.35
ANPEP P15144 4/20 0.35
RNPEP Q9H4A4 1/20 0.35
DNPEP Q9ULA0 1/20 0.35
ALPI P09923 1/20 0.34
PKM P14618 1/20 0.34
PTGS1 P23219 1/20 0.34
XIAP P98170 1/20 0.34
SLC7A5 Q01650 1/20 0.34
ATM Q13315 1/20 0.34
SLC6A2 P23975 2/20 0.33
TAAR1 Q96RJ0 2/20 0.33
MAOA P21397 1/20 0.33
SLC6A4 P31645 1/20 0.33
SLC6A3 Q01959 1/20 0.33
SIGMAR1 Q99720 1/20 0.33
CYP2A6 P11509 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8660600 0.86 ABCB1 (0.37) ATMTAAR1
SCHEMBL6925970 0.84 SLC15A1 (0.42) SLC15A1CSNK1ELTA4HLAP3ANPEP
SCHEMBL28438381 0.80 CSNK1E (0.40) SLC15A1CSNK1ELTA4HLAP3ANPEP
SCHEMBL5838743 0.77 CSNK1E (0.38) SLC15A1CSNK1ELAP3ANPEPRNPEP
SCHEMBL28233244 0.77 CYP1A2 (0.41) ALPIPKMPTGS1XIAPSLC7A5
SCHEMBL6400372 0.74 OPRK1 (0.40) ATMTAAR1
SCHEMBL4729192 0.74 OPRK1 (0.40) ATMTAAR1
SCHEMBL27507556 0.73 ATM (0.41) ATM
SCHEMBL6165008 0.73 TAAR1 (0.38) LAP3ATMSLC6A2TAAR1MAOA
SCHEMBL8827814 0.73 TAAR1 (0.38) ATMSLC6A2TAAR1MAOASLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0801640-B1 2,5-DIAMINO-3,4-DISUBSTITUTED-1,6-DIPHENYLHEXANE ISOSTERES COMPRISING BENZAMIDE, SULFONAMIDE AND ANTHRANILAMIDE SUBUNITS AND METHODS OF USING SAME USA (US) 2003-03-26 EP disclosed
US-5763464-A TREATING HUMAN IMMUNODEFICIENCY VIRUS INFECTIONS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1998-06-09 US disclosed
US-5728718-A RETROVIRAL PROTEASE INHIBITOR; TREATMENT OF HTLV THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1998-03-17 US disclosed
WO-1996019437-A1 2,5-DIAMINO-3,4-DISUBSTITUTED-1,6-DIPHENYLHEXANE ISOSTERES COMPRISING BENZAMIDE, SULFONAMIDE AND ANTHRANILAMIDE SUBUNITS AND METHODS OF USING SAME THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1996-06-27 WO disclosed