Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749718 | 0.91 | ALDH1A1 (0.47) | TDP1CYP1A2HTTALDH1A1TSHR | |
| SCHEMBL13319292 | 0.84 | TDP1 (0.54) | TDP1CYP1A2HTTHSD11B1HTR1A | |
| SCHEMBL26110865 | 0.79 | ALDH1A1 (0.47) | HTTHSD11B1ALDH1A1TSHRPOLB | |
| SCHEMBL12538260 | 0.77 | ALDH1A1 (0.45) | HTTHSD11B1ALDH1A1TSHRPOLB | |
| SCHEMBL303850 | 0.76 | TDP1 (0.54) | TDP1CYP1A2HTR1AALDH1A1MAPT | |
| SCHEMBL7575410 | 0.76 | CHRNB2 (0.47) | HSD11B1ALDH1A1TSHR | |
| SCHEMBL303849 | 0.74 | CYP1A2 (0.52) | TDP1CYP1A2HTTHSD11B1HTR1A | |
| SCHEMBL15934198 | 0.74 | CYP1A2 (0.52) | TDP1CYP1A2HTTHSD11B1HTR1A | |
| SCHEMBL18823195 | 0.74 | CYP1A2 (0.52) | TDP1CYP1A2HTTHSD11B1HTR1A | |
| SCHEMBL15061808 | 0.74 | CYP1A2 (0.52) | TDP1CYP1A2HTTHSD11B1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187847-B1 | STREPTOGRAMIN DERIVATIVES, PREPARATION AND COMPOSITIONS CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-12-03 | — | — | EP | disclosed |
| EP-1187847-A1 | STREPTOGRAMIN DERIVATIVES, PREPARATION AND COMPOSITIONS CONTAINING THEM | Aventis Pharma S.A. (FR) | 2002-03-20 | — | — | EP | disclosed |
| WO-2001002427-A1 | STREPTOGRAMIN DERIVATIVES, PREPARATION AND COMPOSITIONS CONTAINING THEM | AVENTIS PHARMA S.A. (FR) | 2001-01-11 | — | — | WO | disclosed |