Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 9/20 | 0.45 |
| ▸ | KCNQ1 | P51787 | 9/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6932454 | 0.85 | KCNE1 (0.33) | KCNE1KCNQ1CNR2 | |
| SCHEMBL6559524 | 0.76 | KCNE1 (0.57) | KCNE1KCNQ1MEN1CYP1A2CYP3A4 | |
| SCHEMBL6932378 | 0.75 | CNR2 (0.37) | CNR2 | |
| SCHEMBL6932031 | 0.70 | MAOA (0.52) | — | |
| SCHEMBL6936636 | 0.69 | TRPV1 (0.38) | MEN1KMT2ACNR2 | |
| SCHEMBL19210033 | 0.68 | CYSLTR2 (0.41) | CNR2 | |
| SCHEMBL8173197 | 0.68 | HTT (0.56) | — | |
| SCHEMBL30839578 | 0.67 | HTR2A (0.39) | HSD17B10MEN1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL11524465 | 0.67 | HTR2A (0.39) | HSD17B10MEN1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL30886993 | 0.67 | HTR2A (0.39) | HSD17B10MEN1CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915087-B1 | Sulfonamide substituted fused five-membered ring compounds, their use as medicaments as well as pharmaceutical compositions containing them | AVENTIS PHARMA GMBH (DE) | 2003-04-02 | — | — | EP | disclosed |
| US-6015822-A | ANTIULCER, ANTIDIARRHEA, AND ANTIARRHYTHMIA AGENTS; CARDIOVASCULAR AND GASTROINTESTINAL DISORDERS | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) | 2000-01-18 | — | — | US | disclosed |
| EP-0915087-A2 | Sulfonamide substituted fused five-membered ring compounds, their use as medicaments as well as pharmaceutical compositions containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-05-12 | — | — | EP | disclosed |