Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 3/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9844319 | 0.91 | PARP1 (0.63) | KDM4CPARP1PDE10ATNKS2HCAR2 | |
| SCHEMBL7197836 | 0.90 | PARP1 (0.58) | KDM4CPARP1PDE10AHCAR2 | |
| SCHEMBL20355457 | 0.82 | PDE10A (0.45) | PARP1PDE10ATNKS2NPC1RAB9A | |
| SCHEMBL21072816 | 0.81 | KDM4E (0.43) | PARP1PDE10ATNKS2NPC1RAB9A | |
| SCHEMBL20339510 | 0.81 | PARP1 (0.66) | PARP1PDE10ATNKS2SMN1; SMN2PARP2 | |
| SCHEMBL9853629 | 0.78 | KDM4C (0.48) | KDM4CPARP1PDE10ANPC1RAB9A | |
| SCHEMBL29431542 | 0.76 | PARP1 (0.82) | KDM4CPARP1PDE10ATNKS2NPC1 | |
| SCHEMBL5794718 | 0.76 | PARP1 (0.82) | KDM4CPARP1PDE10ATNKS2NPC1 | |
| SCHEMBL9432425 | 0.76 | KDM4C (0.50) | KDM4CPARP1PDE10ATNKS2HTT | |
| SCHEMBL14281531 | 0.76 | PARP1 (0.56) | PARP1TNKS2NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1365806-A2 | USE OF NO ACTTIVATORS FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS | JOHNS HOPKINS UNIVERSITY (US) | 2003-12-03 | — | — | EP | disclosed |
| WO-2001078781-A9 | METHODS FOR PREVENTION AND TREATMENT OF GASTROINTESTINAL DISORDERS | UNIV JOHNS HOPKINS (US) | 2002-07-25 | — | — | WO | disclosed |
| WO-2001078781-A2 | METHODS FOR PREVENTION AND TREATMENT OF GASTROINTESTINAL DISORDERS | JOHNS HOPKINS UNIVERSITY (US) | 2001-10-25 | — | — | WO | disclosed |