Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.58 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9844319 | 0.96 | PARP1 (0.63) | PARP1HCAR2PDE10AKDM4C | |
| SCHEMBL6933543 | 0.90 | KDM4C (0.54) | PARP1HCAR2PDE10AKDM4C | |
| SCHEMBL20355457 | 0.79 | PDE10A (0.45) | PARP1HCAR2PDE10APOLB | |
| SCHEMBL1586541 | 0.78 | PARP1 (0.91) | PARP1PDE10A | |
| SCHEMBL21072816 | 0.78 | KDM4E (0.43) | PARP1PDE10A | |
| SCHEMBL20339510 | 0.78 | PARP1 (0.66) | PARP1PDE10APOLB | |
| SCHEMBL7197832 | 0.78 | GPR84 (0.43) | PARP1HCAR2GPR84POLB | |
| SCHEMBL30176973 | 0.77 | PARP1 (0.89) | PARP1PDE10A | |
| SCHEMBL14621928 | 0.77 | PARP1 (0.89) | PARP1PDE10A | |
| SCHEMBL30176861 | 0.77 | PARP1 (0.89) | PARP1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6534511-B1 | The use of certain 6-arylpyrazolo(3,4-d)pyrimidin-4-ones, 2 arylquinazolin-4-ones, 2-arylpurin-6-ones and 2-arylpyrido(3,2- d)pyrimidin-4-ones, or a pharmaceutically acceptable salt thereof, forsexual disorders | PFIZER INC. | 2003-03-18 | — | — | US | disclosed |
| EP-0793498-B1 | BICYCLIC HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF IMPOTENCE | PFIZER LTD (GB) | 2002-12-11 | — | — | EP | disclosed |
| US-6225315-B1 | ADMINISTERING A CGMP PDE INHIBITOR. | PFIZER INC | 2001-05-01 | — | — | US | disclosed |
| EP-1022026-A2 | Pharmaceutical compositions for treating nitrate-induced tolerance | Pfizer Limited (GB) | 2000-07-26 | — | — | EP | disclosed |
| EP-0793498-A1 | BICYCLIC HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF IMPOTENCE | Pfizer Limited (GB) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016657-A1 | BICYCLIC HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF IMPOTENCE | PFIZER LIMITED (GB) | 1996-06-06 | — | — | WO | disclosed |