Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 6/20 | 0.60 |
| ▸ | NPC1 | O15118 | 6/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7769542 | 0.87 | HDAC3 (0.65) | MAPTALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL28497894 | 0.81 | NPC1 (0.63) | MAPTALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL28495995 | 0.80 | ALDH1A1 (0.67) | MAPTALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL9787091 | 0.80 | ALDH1A1 (0.59) | MAPTALDH1A1HTTMAPK1LMNA | |
| SCHEMBL3193858 | 0.80 | ALDH1A1 (0.59) | MAPTALDH1A1HTTMAPK1LMNA | |
| SCHEMBL6838525 | 0.80 | HDAC3 (0.60) | ALDH1A1HTTLMNASMN1; SMN2RAB9A | |
| SCHEMBL7637081 | 0.80 | RAB9A (0.68) | MAPTALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL2395083 | 0.80 | ALDH1A1 (0.65) | MAPTALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL10926166 | 0.79 | NPC1 (0.59) | MAPTALDH1A1HTTHSD17B10LMNA | |
| SCHEMBL171415 | 0.79 | SMN1; SMN2 (0.73) | MAPTALDH1A1HTTHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756388-B1 | HAVING PIPERIDINYL AND PHENOLIC FUNCTIONALITY; BONE LOSS; BREAST OR PROSTATE CANCER | PFIZER INC. | 2004-06-29 | — | — | US | disclosed |
| EP-0723537-A1 | BENZOTHIOPHENES AND RELATED COMPOUNDS AS ESTROGEN AGONISTS | PFIZER INC. (US) | 1996-07-31 | — | — | EP | disclosed |
| WO-1995010513-A1 | BENZOTHIOPHENES AND RELATED COMPOUNDS AS ESTROGEN AGONISTS | PFIZER INC. (US) | 1995-04-20 | — | — | WO | disclosed |