Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | F2 | P00734 | 2/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.50 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.50 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.48 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL731549 | 0.84 | CYP2D6 (0.55) | ALDH1A1KMT2APKMCYP2D6CYP2C9 | |
| Urea SCHEMBL8693555 | 0.82 | CYP2D6 (0.53) | ALDH1A1KMT2APKMCYP2D6CYP2C9 | |
| SCHEMBL10718657 | 0.82 | CYP2D6 (0.53) | ALDH1A1KMT2APKMCYP2D6CYP2C9 | |
| SCHEMBL8692307 | 0.78 | CYP2D6 (0.56) | ALDH1A1KMT2APKMCYP2D6CYP2C9 | |
| SCHEMBL10752445 | 0.78 | ALDH1A1 (0.56) | ALDH1A1KMT2APKMCYP2D6CYP2C9 | |
| SCHEMBL14417207 | 0.76 | CYP2D6 (0.55) | ALDH1A1KMT2APKMCYP2D6CYP2C9 | |
| SCHEMBL10750707 | 0.76 | ALDH1A1 (0.53) | ALDH1A1KMT2APKMCYP2D6CYP2C9 | |
| SCHEMBL1863910 | 0.75 | CYP2D6 (0.62) | ALDH1A1KMT2APKMCYP2D6CYP2C9 | |
| SCHEMBL8232303 | 0.75 | CYP2D6 (0.62) | ALDH1A1KMT2APKMCYP2D6CYP2C9 | |
| SCHEMBL24254325 | 0.74 | CYP2D6 (0.67) | ALDH1A1KMT2ACYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729954-B1 | Substituted thiophene sulfonyl ureas and thioureas, process for their preparation, their use as medicaments | HOECHST AG (DE) | 2003-09-03 | — | — | EP | claimed |
| CN-1071752-C | Substituted thiophenesulfonylureas and-thioureas, processes for their preparation, their use as medicament or diagnostic, and medicament containing them | HOECHST AG (DE) | 2001-09-26 | — | — | CN | claimed |
| US-5792788-A | FOR TREATMENT OF CARDIAC DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-08-11 | — | — | US | claimed |
| CN-1134421-A | Substituted thiophenesulfonylureas and-thioureas, processes for their preparation, their use as medicament or diagnostic, and medicament containing them | HOECHST AG (DE) | 1996-10-30 | — | — | CN | claimed |
| CN-1071752-C | Substituted thiophenesulfonylureas and-thioureas, processes for their preparation, their use as medicament or diagnostic, and medicament containing them | HOECHST AG (DE) | 2001-09-26 | — | — | CN | disclosed |
| EP-0885216-A1 | SUBSTITUTED THIENYL SULPHONYL (THIO) UREAS AS HERBICIDES | BAYER AG (DE) | 1998-12-23 | — | — | EP | disclosed |
| US-5792788-A | FOR TREATMENT OF CARDIAC DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-08-11 | — | — | US | disclosed |
| WO-1997032875-A1 | SUBSTITUTED THIENYL SULPHONYL (THIO) UREAS AS HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1997-09-12 | — | — | WO | disclosed |
| CN-1134421-A | Substituted thiophenesulfonylureas and-thioureas, processes for their preparation, their use as medicament or diagnostic, and medicament containing them | HOECHST AG (DE) | 1996-10-30 | — | — | CN | disclosed |
| US-4639265-A | PRE- AND POSTEMERGENCE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1987-01-27 | — | — | US | disclosed |
| EP-0064804-B1 | THIOPHENE HERBICIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |
| US-4547217-A | ESPECIALLY FOR CORN | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-10-15 | — | — | US | disclosed |
| US-4441910-A | PRE- AND POST-EMERGENCE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-04-10 | — | — | US | disclosed |
| EP-0064804-A2 | Thiophene herbicides | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-11-17 | — | — | EP | disclosed |