Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 3/20 | 0.33 |
| ▸ | MMP8 | P22894 | 2/20 | 0.33 |
| ▸ | MMP13 | P45452 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 2/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 2/20 | 0.32 |
| ▸ | MMP7 | P09237 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP12 | P39900 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10339328 | 0.77 | NR1I2 (0.42) | GRM5RAB9AL3MBTL1POLBMAPK1 | |
| SCHEMBL10188257 | 0.75 | SCN9A (0.41) | ADAM17RAB9ARXRAGRIN1GRIN2B | |
| SCHEMBL10933335 | 0.71 | MAPK1 (0.61) | MEN1KMT2APOLBMAPK1HSD17B10 | |
| SCHEMBL17039196 | 0.71 | MAPT (0.31) | — | |
| SCHEMBL6219019 | 0.69 | MAPT (0.54) | RAB9AMEN1KMT2APOLBMAPK1 | |
| SCHEMBL15274643 | 0.69 | ADAM17 (0.58) | ADAM17MMP2MMP8MMP13MMP9 | |
| SCHEMBL6265267 | 0.68 | KCNH2 (0.55) | ADAM17MMP2MMP8MMP13MMP9 | |
| SCHEMBL9338770 | 0.68 | KCNH2 (0.55) | ADAM17MMP2MMP8MMP13MMP9 | |
| SCHEMBL22468784 | 0.67 | SMN1; SMN2 (0.42) | RAB9A | |
| SCHEMBL2269826 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1366026-A2 | PYRIMIDINE COMPOUNDS AND THEIR USE | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2003-12-03 | — | — | EP | disclosed |
| WO-2002024663-A2 | PYRIMIDINE COMPOUNDS AND THEIR USE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2002-03-28 | — | — | WO | disclosed |