Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.91 |
| ▸ | HPGD | P15428 | 6/20 | 0.91 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.91 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | CA1 | P00915 | 2/20 | 0.58 |
| ▸ | CA9 | Q16790 | 2/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.58 |
| ▸ | CA4 | P22748 | 1/20 | 0.58 |
| ▸ | CA6 | P23280 | 1/20 | 0.58 |
| ▸ | CA7 | P43166 | 1/20 | 0.58 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.58 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MPO | P05164 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL6249450 | 0.97 | KDM4E (0.95) | KDM4EHPGDALDH1A1SMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL6029949 | 0.95 | KDM4E (0.91) | KDM4EHPGDALDH1A1SMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL11599872 | 0.95 | KDM4E (0.91) | KDM4EHPGDALDH1A1SMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL12477385 | 0.95 | KDM4E (0.91) | KDM4EHPGDALDH1A1SMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL11514957 | 0.95 | KDM4E (0.91) | KDM4EHPGDALDH1A1SMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL458273 | 0.95 | KDM4E (0.91) | KDM4EHPGDALDH1A1SMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL9981 | 0.95 | KDM4E (0.91) | KDM4EHPGDALDH1A1SMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL3132735 | 0.95 | KDM4E (0.91) | KDM4EHPGDALDH1A1SMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL1026592 | 0.95 | KDM4E (0.91) | KDM4EHPGDALDH1A1SMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL546852 | 0.95 | KDM4E (0.91) | KDM4EHPGDALDH1A1SMN1; SMN2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1013715-B1 | Room temperature vulcanizing silicone rubber compositions and process for making | DOW CORNING (US) | 2003-03-26 | — | — | EP | disclosed |
| EP-1013715-A2 | Room temperature vulcanizing silicone rubber compositions and process for making | DOW CORNING CORPORATION (US) | 2000-06-28 | — | — | EP | disclosed |
| US-5990231-A | COMPRISING A SILANOL END-TERMINATED POLYORGANOSILOXANE BASE POLYMER, AN ORGANOTRIACYLOXYSILANE, A POLYSILOXANE-POLYETHER COPOLYMER AS A FLOW CONTROL AGENT TO CONTROL THE VISCOSITY AND PLATEAU STRESS AND SILICA; SEALS AND CAULKING | DOW CORNING CORPORATION (US) | 1999-11-23 | — | — | US | disclosed |
| EP-0543292-B1 | A flame retardant elastomeric composition | WACKER CHEMIE GMBH (DE) | 1995-02-08 | — | — | EP | disclosed |
| US-5260372-A | Polysilxoanes | WACKER SILICONES CORPORATION (US) | 1993-11-09 | — | — | US | disclosed |
| EP-0543292-A1 | A flame retardant elastomeric composition | WACKER-CHEMIE GMBH (DE) | 1993-05-26 | — | — | EP | disclosed |
| US-4461854-A | ENCAPSULATED METALLIC CARBOXYLIC ACID SALT | GENERAL ELECTRIC COMPANY (US) | 1984-07-24 | — | — | US | disclosed |
| US-4304897-A | TRIACYLOXYALKYLSILANE, POLYETHERSILOXANE COPOLYMER, SILICONE OIL | GENERAL ELECTRIC COMPANY (US) | 1981-12-08 | — | — | US | disclosed |
| US-4077822-A | Splice for use during the thermal stabilization of a flat multifilament band of an acrylic fibrous material comprising at least two segments | CELANESE CORPORATION (US) | 1978-03-07 | — | — | US | disclosed |