Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 9/20 | 0.46 |
| ▸ | MMP3 | P08254 | 8/20 | 0.46 |
| ▸ | MMP1 | P03956 | 8/20 | 0.46 |
| ▸ | MMP2 | P08253 | 3/20 | 0.46 |
| ▸ | MMP13 | P45452 | 2/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | MME | P08473 | 3/20 | 0.40 |
| ▸ | GRN | P28799 | 1/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6935034 | 1.00 | MMP9 (0.46) | MMP9MMP3MMP1MMP2MMP13 | |
| SCHEMBL14156438 | 0.86 | MMP1 (0.67) | MMP9MMP3MMP1MMP2MMP13 | |
| SCHEMBL6766456 | 0.86 | MMP1 (0.67) | MMP9MMP3MMP1MMP2MMP13 | |
| SCHEMBL4820309 | 0.84 | PLA2G7 (0.46) | MMP9MMP3MMP1MMP2MMP13 | |
| SCHEMBL4820321 | 0.84 | PLA2G7 (0.46) | MMP9MMP3MMP1MMP2MMP13 | |
| SCHEMBL4824816 | 0.84 | PLA2G7 (0.46) | MMP9MMP3MMP1MMP2MMP13 | |
| SCHEMBL14156580 | 0.78 | PLA2G7 (0.47) | MMP9MMP3MMP1MMP2MMP13 | |
| SCHEMBL14163518 | 0.78 | PLA2G7 (0.47) | MMP9MMP3MMP1MMP2MMP13 | |
| SCHEMBL4787630 | 0.78 | MMP9 (0.70) | MMP9MMP3MMP1MMP2MMP13 | |
| SCHEMBL6547584 | 0.78 | MMP9 (0.70) | MMP9MMP3MMP1MMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123410-B1 | THE ENZYME-MEDIATED SYNTHESIS OF PEPTIDOMIMETICS | DARWIN DISCOVERY LTD (GB) | 2003-12-10 | — | — | EP | disclosed |
| US-6436697-B1 | AMIDATION REACTION OF ORGANOYLSULFANYLALKYLCARBOXYL DERIVATIVE WITH PRIMARY AMINE; ENZYME-MEDIATED COUPLING USING THERMOLYSIN OR SUBTILISIN; AMIDATION, DEBLOCKING, DEPROTECTING | DARWIN DISCOVERY, LTD. (GB) | 2002-08-20 | — | — | US | disclosed |