Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.34 |
| ▸ | SELE | P16581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6935062 | 0.90 | ICAM1 (0.40) | SLC9A1KCNH2ICAM1SELE | |
| SCHEMBL6935256 | 0.90 | SLC9A1 (0.38) | SLC9A1KCNH2ICAM1SELE | |
| SCHEMBL6936971 | 0.89 | PLAU (0.40) | SLC9A1KCNH2ICAM1SELE | |
| SCHEMBL6935364 | 0.89 | SLC9A1 (0.43) | SLC9A1 | |
| SCHEMBL6935394 | 0.87 | SLC9A1 (0.45) | SLC9A1KCNH2 | |
| SCHEMBL6933342 | 0.84 | SLC9A1 (0.39) | SLC9A1KCNH2 | |
| SCHEMBL6935163 | 0.83 | SLC6A2 (0.42) | SLC9A1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL6935108 | 0.83 | SLC9A1 (0.40) | SLC9A1KCNH2ICAM1SELE | |
| SCHEMBL6932306 | 0.82 | SLC9A1 (0.40) | SLC9A1KCNH2 | |
| SCHEMBL6932344 | 0.80 | SLC9A1 (0.39) | SLC9A1KCNH2ICAM1SELE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758644-B1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GMBH (DE) | 2003-10-15 | — | — | EP | disclosed |
| US-5744641-A | Sulfonyl- or sulfinylbenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-28 | — | — | US | disclosed |
| EP-0758644-A1 | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | MERCK PATENT GmbH (DE) | 1997-02-19 | — | — | EP | disclosed |