Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14363621 | 0.81 | HTT (0.68) | L3MBTL1HTTMAPTTP53KDM4E | |
| SCHEMBL8554106 | 0.79 | L3MBTL1 (0.56) | L3MBTL1HTTTP53TSHRNPC1 | |
| SCHEMBL8045416 | 0.79 | S1PR1 (0.68) | L3MBTL1HTTMAPTS1PR1 | |
| SCHEMBL12717346 | 0.79 | MAPT (0.46) | L3MBTL1HTTMAPTTP53KDM4E | |
| SCHEMBL30509199 | 0.76 | HTT (0.57) | L3MBTL1HTTMAPTKDM4ES1PR1 | |
| SCHEMBL428750 | 0.76 | HTT (0.57) | L3MBTL1HTTMAPTKDM4ES1PR1 | |
| SCHEMBL12266913 | 0.75 | L3MBTL1 (0.57) | L3MBTL1HTTMAPTTP53KDM4E | |
| SCHEMBL20116544 | 0.74 | SMN1; SMN2 (0.73) | HTTMAPTKDM4ES1PR1HSD17B10 | |
| SCHEMBL8977892 | 0.73 | L3MBTL1 (0.50) | L3MBTL1HTTTP53TSHRNPC1 | |
| SCHEMBL16481858 | 0.73 | L3MBTL1 (0.50) | L3MBTL1HTTMAPTKDM4ES1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114275-A1 | SPIROCYCLIC COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | UNIVERSITY OF BASEL (CH) | 2011-09-22 | — | — | WO | disclosed |