Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3787975 | 0.88 | PKM (0.40) | L3MBTL1SMN1; SMN2LMNARAB9AHSD17B10 | |
| SCHEMBL618089 | 0.81 | POLB (0.58) | L3MBTL1SMN1; SMN2LMNARAB9AKMT2A | |
| SCHEMBL4770342 | 0.73 | KDM4E (0.43) | L3MBTL1HSD17B10MAPK10TDP1TSHR | |
| SCHEMBL6338427 | 0.72 | CAMKK2 (0.43) | SMN1; SMN2HSD17B10MAPK10ALDH1A1KDM4E | |
| SCHEMBL29447914 | 0.71 | KDM4E (0.63) | L3MBTL1SMN1; SMN2LMNARAB9AKMT2A | |
| SCHEMBL1217220 | 0.71 | KDM4E (0.63) | L3MBTL1SMN1; SMN2LMNARAB9AKMT2A | |
| SCHEMBL699555 | 0.71 | SMN1; SMN2 (0.38) | SMN1; SMN2LMNARAB9AHSD17B10MAPK10 | |
| SCHEMBL6286484 | 0.69 | POLB (0.46) | L3MBTL1LMNARAB9AKMT2AMEN1 | |
| SCHEMBL1080763 | 0.68 | KDM4E (0.62) | L3MBTL1SMN1; SMN2TDP1POLBALDH1A1 | |
| SCHEMBL28098788 | 0.67 | MAP2K1 (0.41) | HSD17B10MAPK10KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421366-A1 | HETEROCYCLIC FUSED CINNOLINE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck Sharp & Dohme Corp. (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010123716-A1 | HETEROCYCLIC FUSED CINNOLINE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-28 | — | — | WO | disclosed |