Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 13/20 | 0.39 |
| ▸ | METAP1 | P53582 | 8/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6478812 | 0.77 | METAP2 (0.47) | METAP2METAP1ALDH1A1TDP1 | |
| SCHEMBL7068948 | 0.77 | METAP2 (0.39) | METAP2METAP1 | |
| SCHEMBL6938188 | 0.74 | METAP2 (0.43) | METAP2METAP1 | |
| SCHEMBL6935512 | 0.68 | METAP2 (0.43) | METAP2METAP1 | |
| SCHEMBL6939440 | 0.66 | METAP2 (0.56) | METAP2METAP1 | |
| SCHEMBL6942554 | 0.66 | METAP2 (0.45) | METAP2METAP1 | |
| SCHEMBL6939437 | 0.66 | METAP2 (0.40) | METAP2METAP1 | |
| SCHEMBL6937626 | 0.65 | METAP2 (0.47) | METAP2METAP1 | |
| SCHEMBL6477637 | 0.65 | METAP2 (0.57) | METAP2METAP1 | |
| SCHEMBL6238982 | 0.65 | METAP2 (0.57) | METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272456-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2003-01-08 | — | — | EP | claimed |
| WO-2001079157-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2001-10-25 | — | — | WO | claimed |