Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.45 |
| ▸ | NPC1 | O15118 | 9/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25599144 | 0.77 | MAPT (0.45) | RAB9ANPC1MAPTATMKDM4E | |
| SCHEMBL25598176 | 0.76 | SMN1; SMN2 (0.54) | RAB9ANPC1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL25599154 | 0.75 | F13A1 (0.44) | RAB9ANPC1MAPTATMKDM4E | |
| SCHEMBL25680363 | 0.74 | NPC1 (0.48) | RAB9ANPC1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL25681675 | 0.74 | SMN1; SMN2 (0.42) | RAB9ANPC1MAPTATMKDM4E | |
| SCHEMBL25599129 | 0.73 | SMN1; SMN2 (0.43) | RAB9ANPC1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL25598763 | 0.73 | ALDH1A1 (0.70) | RAB9ANPC1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL25735906 | 0.71 | SMN1; SMN2 (0.68) | RAB9AMAPTATMKDM4ESMN1; SMN2 | |
| SCHEMBL26630402 | 0.70 | NPC1 (0.55) | RAB9ANPC1MAPTLMNATGM2 | |
| SCHEMBL25597800 | 0.70 | HTR2B (0.54) | RAB9ANPC1MAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114275-A1 | SPIROCYCLIC COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | UNIVERSITY OF BASEL (CH) | 2011-09-22 | — | — | WO | disclosed |