Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.68 |
| ▸ | TP53 | P04637 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | XIAP | P98170 | 1/20 | 0.58 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | BRPF1 | P55201 | 3/20 | 0.52 |
| ▸ | BRD4 | O60885 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.50 |
| ▸ | TGM2 | P21980 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25737033 | 0.90 | SMN1; SMN2 (0.55) | SMN1; SMN2TP53HSD17B10ALDH1A1HTT | |
| SCHEMBL27056788 | 0.86 | SMN1; SMN2 (0.51) | SMN1; SMN2TP53HSD17B10ALDH1A1HTT | |
| SCHEMBL27056782 | 0.77 | PSMB8 (0.51) | SMN1; SMN2TP53HSD17B10LMNABRD4 | |
| SCHEMBL11545418 | 0.76 | SMN1; SMN2 (0.74) | SMN1; SMN2TP53HSD17B10ALDH1A1HTT | |
| SCHEMBL28016711 | 0.75 | TGM2 (0.49) | TP53LMNAMEN1KMT2AMAPT | |
| SCHEMBL25597800 | 0.75 | HTR2B (0.54) | SMN1; SMN2TP53LMNARAB9AMEN1 | |
| SCHEMBL15474185 | 0.74 | XIAP (1.00) | SMN1; SMN2TP53HSD17B10ALDH1A1HTT | |
| SCHEMBL27256654 | 0.73 | SMN1; SMN2 (0.64) | SMN1; SMN2TP53HSD17B10ALDH1A1HTT | |
| SCHEMBL26630402 | 0.72 | NPC1 (0.55) | ALDH1A1LMNARAB9ABRD4MAPT | |
| SCHEMBL25598763 | 0.72 | ALDH1A1 (0.70) | SMN1; SMN2TP53HSD17B10ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240024490-A1 | BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES | THE BROAD INSTITUTE, INC. | 2024-01-25 | — | — | US | disclosed |
| US-20230192904-A1 | BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF | THE BROAD INSTITUTE, INC. | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240024490-A1 | BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES | COASY, JMJD7, PTMS | SMN1; SMN2 3607/4885TP53 1216/4885HSD17B10 527/4885 |
| US-20230192904-A1 | BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF | ERBB2, ACP1, TK1 | SMN1; SMN2 3469/4885TP53 355/4885HSD17B10 3033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.