Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.61 |
| ▸ | CCND1 | P24385 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | AGER | Q15109 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6936381 | 1.00 | CDK4 (0.61) | CDK4CCND1LMNAKMT2AMEN1 | |
| SCHEMBL7149272 | 0.83 | KMT2A (0.66) | CDK4CCND1LMNAKMT2AMEN1 | |
| SCHEMBL30063707 | 0.78 | CDK4 (0.76) | CDK4CCND1LMNAKMT2AMEN1 | |
| SCHEMBL734246 | 0.78 | CDK4 (0.76) | CDK4CCND1LMNAKMT2AMEN1 | |
| SCHEMBL11366447 | 0.78 | CDK4 (1.00) | CDK4CCND1LMNAKMT2AALDH1A1 | |
| SCHEMBL10412119 | 0.77 | CDK4 (0.68) | CDK4CCND1LMNAKMT2AHTR2A | |
| SCHEMBL29928685 | 0.77 | CDK4 (0.68) | CDK4CCND1LMNAKMT2AHTR2A | |
| SCHEMBL16603958 | 0.77 | AGER (0.71) | CDK4CCND1LMNAKMT2AMEN1 | |
| SCHEMBL27518021 | 0.77 | CDK4 (0.73) | CDK4CCND1LMNAKMT2AMEN1 | |
| SCHEMBL6689749 | 0.77 | MEN1 (0.67) | CDK4CCND1LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596738-B1 | Inhibiting activity to adenosine deaminase (hereinafter described as ADA) An adenosine deaminase inhibiting agent comprising a compound of the formula (I): | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-07-22 | — | — | US | disclosed |
| EP-1161429-A2 | HETEROCYCLIC COMPOUNDS AS ADENOSINE DEAMINASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000055155-A2 | HETEROCYCLIC COMPOUNDS AS ADENOSINE DEAMINASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-09-21 | — | — | WO | disclosed |