Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 2/20 | 0.44 |
| ▸ | TNKS | O95271 | 3/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL6932552 | 0.98 | HPRT1 (0.43) | HPRT1TNKSTNKS2LTB4R2LMNA | |
| SCHEMBL930873 | 0.78 | HPRT1 (0.47) | HPRT1LMNAMEN1KMT2AALDH1A1 | |
| Water SCHEMBL6931313 | 0.77 | HPRT1 (0.46) | HPRT1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL1866525 | 0.72 | HPRT1 (0.58) | HPRT1ALDH1A1 | |
| SCHEMBL8768185 | 0.69 | HPRT1 (0.54) | HPRT1KMT2AKDM4EALDH1A1TDP1 | |
| SCHEMBL7684221 | 0.69 | HPRT1 (0.45) | HPRT1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL4240951 | 0.68 | ALDH1A1 (0.49) | LMNATP53MEN1KMT2AL3MBTL1 | |
| SCHEMBL4683525 | 0.65 | LTB4R2 (0.46) | LTB4R2TP53MEN1KMT2AALDH1A1 | |
| SCHEMBL1248604 | 0.63 | HPRT1 (0.37) | HPRT1LMNAMEN1KMT2AKDM4E | |
| SCHEMBL931907 | 0.63 | MAPT (0.43) | HPRT1LMNATP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368350-A1 | NOVEL CRYSTAL FORMS OF 9-SUBSTITUTED HYPOXANTHINE DERIVATIVES | Neotherapeutics, Inc. (US) | 2003-12-10 | — | — | EP | disclosed |
| WO-2003011863-A1 | NOVEL CRYSTAL FORMS OF 9-SUBSTITUTED HYPOXANTHINE DERIVATIVES | NEOTHERAPEUTICS, INC. (US) | 2003-02-13 | — | — | WO | disclosed |
| US-6407237-B1 | SALT FORMATION WITH POTASSIUM HYDROXIDE; PRECIPITATION INETHANOL; CRYSTALLIZATION | NEOTHERAPEUTICS, INC. | 2002-06-18 | — | — | US | disclosed |