Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3963512 | 0.98 | GSK3A (0.43) | GSK3AGSK3BMEN1KMT2AALDH1A1 | |
| SCHEMBL6938267 | 0.85 | ALDH1A1 (0.46) | GSK3BKMT2AALDH1A1RAB9AMAPT | |
| Bromide SCHEMBL2945063 | 0.84 | ALDH1A1 (0.45) | GSK3BKMT2AALDH1A1NPC1RAB9A | |
| Bromide SCHEMBL4078658 | 0.80 | ALDH1A1 (0.42) | GSK3BKMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL1820216 | 0.72 | ALDH1A1 (0.46) | GSK3AGSK3BMEN1KMT2AALDH1A1 | |
| SCHEMBL2920557 | 0.71 | ALDH1A1 (0.44) | GSK3AGSK3BMEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL33828 | 0.71 | RAB9A (0.46) | GSK3AGSK3BMEN1KMT2AALDH1A1 | |
| Bromide SCHEMBL2954276 | 0.71 | ALDH1A1 (0.48) | GSK3AGSK3BMEN1KMT2AALDH1A1 | |
| Bromide SCHEMBL122634 | 0.70 | ALDH1A1 (0.43) | GSK3AGSK3BMEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL4019649 | 0.70 | ALDH1A1 (0.43) | GSK3AGSK3BMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE38330-E1 | Preventing and reversing advanced glycosylation endproducts | ALTEON INC. | 2003-11-25 | — | — | US | claimed |
| EP-0808163-B1 | USE OF THIAZOLIUM COMPOUNDS FOR PREVENTING AND REVERSING THE FORMATION OF ADVANCED GLYCOSYLATION ENDPRODUCTS | ALTEON INC (US) | 2003-07-23 | — | — | EP | claimed |
| US-6440749-B1 | ADMINISTERING A THIAZOLE COMPOUND | ALTEON. INC. | 2002-08-27 | — | — | US | claimed |
| US-6007865-A | FOR INHIBITING AND REVERSING NONENZYMATIC CROSS-LINKING (PROTEIN AGING), TREATING KIDNEY DAMAGE AND TREATING COMPLICATIONS OF DIABETES, PREVENTING FOOD SPOILAGE | ALTEON INC. | 1999-12-28 | — | — | US | disclosed |