Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.49 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.49 |
| ▸ | TLR3 | O15455 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10752810 | 0.82 | TLR3 (0.70) | HIF1AEPAS1TLR3 | |
| SCHEMBL6935054 | 0.79 | HIF1A (0.43) | CA12CA1CA9HIF1AEPAS1 | |
| SCHEMBL14541294 | 0.77 | HIF1A (0.56) | HIF1AEPAS1 | |
| SCHEMBL10767556 | 0.76 | MAOB (0.53) | CA2TLR3MAOBMAOACA5A | |
| SCHEMBL2009830 | 0.76 | HIF1A (0.52) | CA12CA1CA9HIF1AEPAS1 | |
| SCHEMBL31253964 | 0.75 | TLR3 (0.42) | HIF1AEPAS1TLR3MAOBMAOA | |
| SCHEMBL4552597 | 0.74 | COXFA4 (0.54) | HIF1AEPAS1TLR3 | |
| SCHEMBL31253973 | 0.74 | MAPT (0.39) | HIF1AEPAS1TLR3MAOBMAOA | |
| SCHEMBL4017638 | 0.74 | HIF1A (0.42) | CA12CA1CA9HIF1AEPAS1 | |
| SCHEMBL6937184 | 0.74 | KCNE1 (0.45) | HIF1AEPAS1TLR3MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0913396-B1 | Sulphonamide substituted benzopyran derivatives, process of preparation, their use as medicines and pharmaceutical compositions containing them | AVENTIS PHARMA GMBH (DE) | 2003-09-17 | — | — | EP | disclosed |
| US-6008245-A | TREATMENT OF PROPHYLAXIS AND CARDIOVASCULAR DISORDERS, IN PARTICULAR ARRHYTHMIAS, FOR THE TREATMENT OF ULCERS OF THE GASTROINTESTINAL DISORDERS, DIARRHEAL DISEASES | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) | 1999-12-28 | — | — | US | disclosed |
| CN-1218050-A | Sulfonamide-substituted benzopyran derivates processes for their preparation, their use as medicament, and pharmaceutical preparations comprising them | HOECHST MARION ROUSSEL DE GMBH (DE) | 1999-06-02 | — | — | CN | disclosed |
| EP-0913396-A2 | Sulphonamide substituted benzopyran derivatives, process of preparation, their use as medicines and pharmaceutical compositions containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-05-06 | — | — | EP | disclosed |