Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 10/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 10/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2009830 | 0.83 | HIF1A (0.52) | HIF1AEPAS1ALDH1A1HPGDKDM4E | |
| SCHEMBL8802196 | 0.78 | HIF1A (0.43) | HIF1AEPAS1ALDH1A1HPGDKDM4E | |
| SCHEMBL5308630 | 0.78 | HIF1A (0.47) | HIF1AEPAS1 | |
| SCHEMBL4492932 | 0.78 | ALDH1A1 (0.51) | HIF1AEPAS1ALDH1A1HPGDKDM4E | |
| SCHEMBL6935054 | 0.77 | HIF1A (0.43) | HIF1AEPAS1ALDH1A1HPGDKDM4E | |
| SCHEMBL7738844 | 0.74 | HIF1A (0.58) | HIF1AEPAS1ALDH1A1HPGDKDM4E | |
| SCHEMBL3049240 | 0.74 | ALDH1A1 (0.46) | HIF1AEPAS1ALDH1A1HPGDKDM4E | |
| SCHEMBL6936669 | 0.74 | CA2 (0.54) | HIF1AEPAS1CA12CA1CA9 | |
| SCHEMBL6024450 | 0.73 | HTR2C (0.54) | HIF1AEPAS1ALDH1A1HPGDKDM4E | |
| SCHEMBL8723354 | 0.73 | XDH (0.68) | HIF1AEPAS1ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009133970-A1 | CRYSTALLINE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-05 | — | — | WO | disclosed |
| EP-2074117-A2 | HETEROMONOCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008062905-A2 | HETEROMONOCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-29 | — | — | WO | disclosed |