Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 6/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2357274 | 0.86 | SLC6A4 (0.35) | OPRM1OPRL1SLC6A4SLC6A2OPRD1 | |
| SCHEMBL5163207 | 0.84 | OPRM1 (0.44) | OPRM1OPRL1SLC6A4SLC6A2OPRD1 | |
| SCHEMBL5158611 | 0.82 | OPRM1 (0.41) | OPRM1OPRL1SLC6A4SLC6A2OPRD1 | |
| SCHEMBL6936946 | 0.82 | OPRM1 (0.43) | OPRM1OPRL1SLC6A4SLC6A2OPRD1 | |
| SCHEMBL5159940 | 0.81 | OPRM1 (0.40) | OPRM1OPRL1SLC6A4SLC6A2OPRD1 | |
| SCHEMBL6938734 | 0.81 | SLC6A3 (0.46) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL5158062 | 0.80 | OPRM1 (0.41) | OPRM1OPRL1SLC6A4SLC6A2OPRD1 | |
| SCHEMBL6936278 | 0.80 | SLC6A3 (0.44) | OPRM1OPRL1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL5160386 | 0.80 | OPRM1 (0.44) | OPRM1OPRL1SLC6A4SLC6A2OPRD1 | |
| SCHEMBL6941375 | 0.79 | OPRM1 (0.41) | OPRM1OPRL1SLC6A4SLC6A2OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | claimed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | claimed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | claimed |
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |