Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 3/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTR1E | P28566 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5162722 | 0.91 | SLC6A2 (0.45) | SLC6A2SLC6A4OPRM1OPRL1OPRK1 | |
| Hydrochloric Acid SCHEMBL5845093 | 0.90 | SLC6A2 (0.44) | SLC6A2SLC6A4OPRM1OPRL1OPRK1 | |
| SCHEMBL6940292 | 0.86 | SLC6A4 (0.34) | SLC6A2SLC6A4OPRM1CETPSLC6A3 | |
| SCHEMBL7429939 | 0.85 | OPRK1 (0.34) | SLC6A2SLC6A4OPRM1OPRK1CETP | |
| SCHEMBL6937438 | 0.84 | SLC6A2 (0.41) | SLC6A2SLC6A4OPRM1OPRL1GRIN2B | |
| SCHEMBL6939785 | 0.83 | SLC6A2 (0.41) | SLC6A2SLC6A4OPRM1OPRL1CETP | |
| SCHEMBL6940376 | 0.83 | SLC6A4 (0.36) | SLC6A2SLC6A4OPRM1OPRL1OPRK1 | |
| SCHEMBL6936755 | 0.81 | SLC6A2 (0.47) | SLC6A2SLC6A4OPRM1OPRK1ALDH1A1 | |
| SCHEMBL6934438 | 0.81 | OPRK1 (0.40) | SLC6A2SLC6A4OPRM1OPRK1GRIN2B | |
| SCHEMBL5846576 | 0.81 | SLC6A2 (0.40) | SLC6A2SLC6A4OPRM1OPRL1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | claimed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | claimed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | claimed |
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |