Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 1/20 | 0.34 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6676441 | 0.92 | SLC6A2 (0.45) | SLC6A4SLC6A2OPRM1OPRL1SLC6A3 | |
| SCHEMBL5158078 | 0.88 | OPRM1 (0.40) | OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL6936977 | 0.83 | SLC6A2 (0.40) | SLC6A4SLC6A2FFAR1OPRM1OPRL1 | |
| SCHEMBL6940292 | 0.82 | SLC6A4 (0.34) | SLC6A4SLC6A2OPRM1PTGS1KDR | |
| SCHEMBL6938762 | 0.82 | SLC6A3 (0.37) | SLC6A4SLC6A2OPRM1OPRL1SLC6A3 | |
| SCHEMBL6681587 | 0.82 | SLC6A4 (0.41) | SLC6A4SLC6A2OPRM1KDRSLC6A3 | |
| SCHEMBL5159886 | 0.81 | OPRM1 (0.42) | OPRM1OPRL1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL7737764 | 0.80 | OPRM1 (0.41) | OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL7429939 | 0.80 | OPRK1 (0.34) | SLC6A4SLC6A2FFAR1OPRM1PTGS1 | |
| SCHEMBL6936755 | 0.79 | SLC6A2 (0.47) | SLC6A4SLC6A2OPRM1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | claimed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | claimed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | claimed |
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |