Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084175 | 0.81 | HSD17B10 (0.44) | ACHEMEN1MAPTKMT2ACHRNB4 | |
| SCHEMBL28763604 | 0.79 | TAAR1 (0.50) | KDM4EMEN1MAPTKMT2ATAAR1 | |
| SCHEMBL30172706 | 0.78 | KDM4E (0.41) | KDM4EMEN1MAPTKMT2ATAAR1 | |
| SCHEMBL22261519 | 0.78 | KDM4E (0.41) | KDM4EMEN1MAPTKMT2ATAAR1 | |
| SCHEMBL695291 | 0.76 | PTGS1 (0.51) | ACHE | |
| SCHEMBL1825367 | 0.76 | BCAT2 (0.47) | MEN1KMT2AESR2HSD17B10 | |
| SCHEMBL9009002 | 0.75 | HSD17B1 (0.44) | ESR2HSD17B1HSD17B2GAA | |
| SCHEMBL694184 | 0.74 | CYP2A6 (0.53) | ACHEKDM4EMEN1MAPTKMT2A | |
| SCHEMBL24508433 | 0.74 | PTGS1 (0.40) | KDM4EMEN1MAPTKMT2ATAAR1 | |
| SCHEMBL24508434 | 0.73 | BCAT2 (0.50) | KDM4EMEN1MAPTKMT2APIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421825-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2012-02-29 | — | — | EP | claimed |
| WO-2010124108-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | claimed |