Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 11/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.49 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8089263 | 0.82 | PTGS2 (0.49) | PTGS1PTGS2ACHE | |
| SCHEMBL5126984 | 0.78 | KIF11 (0.42) | — | |
| SCHEMBL1825367 | 0.77 | BCAT2 (0.47) | PTGS2PRKCZ | |
| SCHEMBL7163500 | 0.76 | PTGS1 (0.58) | PTGS1MAPK14PTGS2 | |
| SCHEMBL693705 | 0.76 | ACHE (0.42) | ACHE | |
| SCHEMBL10843937 | 0.76 | MAPK14 (0.79) | PTGS1MAPK14PTGS2 | |
| SCHEMBL16887409 | 0.75 | PLA2G10 (0.40) | PTGS2 | |
| SCHEMBL8038496 | 0.75 | PTGS2 (0.51) | PTGS1PTGS2ACHE | |
| SCHEMBL7323658 | 0.74 | MAPK14 (0.50) | PTGS1MAPK14PTGS2 | |
| SCHEMBL9812737 | 0.74 | MAPK14 (0.50) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421825-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2012-02-29 | — | — | EP | claimed |
| WO-2010124108-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | claimed |