Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | KRAS | P01116 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | SNCA | P37840 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL693485 | 0.83 | PTGS1 (0.60) | MAPTCYP3A4KRASALDH1A1HTT | |
| SCHEMBL6920607 | 0.82 | MAPT (0.61) | MAPTCYP3A4KRASALDH1A1HTT | |
| SCHEMBL715972 | 0.82 | PTGS1 (0.43) | MAPTKDM4EPTGS1PTGS2SNCA | |
| SCHEMBL5116259 | 0.80 | PTGS2 (0.76) | PTGS1PTGS2SNCASLC2A1 | |
| SCHEMBL31744679 | 0.80 | KDM4E (0.51) | MAPTCYP3A4KRASALDH1A1HTT | |
| SCHEMBL18383120 | 0.79 | MAPT (0.69) | MAPTCYP3A4KRASALDH1A1HTT | |
| SCHEMBL3078541 | 0.75 | HTT (0.57) | MAPTCYP3A4KRASALDH1A1HTT | |
| SCHEMBL4053484 | 0.74 | MAPT (0.54) | MAPTCYP3A4KRASALDH1A1HTT | |
| SCHEMBL11037210 | 0.74 | KRAS (0.56) | MAPTCYP3A4KRASALDH1A1HTT | |
| SCHEMBL31744696 | 0.74 | MAPT (0.54) | MAPTCYP3A4KRASALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421851-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010124102-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | disclosed |